CW Cheng#, CY Kuo#, CC Fan#, WC Fang, SS Jiang, YK Lo, TY Wang, MC Kao, and Alan Yueh-Luen Lee*. (2013) Overexpression of Lon contributes to survival and aggressive phenotype of cancer cells through mitochondrial complex I-mediated generation of reactive oxygen species. Cell Death and Disease 4: e681 *corresponding author (IF=6.30)
WT Fang, CC Fan, SP Lin, SM Li, NY Shih, CH Chen, TY Wang, SF Huang, Alan Yueh-Luen Lee, YL Liu, FY Tsai, CT Huang, TH Jang, SJ Yang, LJ Yen, CY Chen, CA Hsiung, JY Chang, LH Wang, IS Chang, and SS Jiang. (2014) Downregulation of a putative tumor suppressor BMP4 by SOX2 promotes growth of lung squamous cell carcinoma. International Journal of Cancer 135(4): 809-19.
TY Kao , YC Chiu, WC Fang, CW Cheng, CY Kuo, HF Juan, SH Wu*, and Alan Yueh-Luen Lee*. (2015) Mitochondrial Lon regulates apoptosis through the association with Hsp60-mtHsp70 complex. Cell Death and Disease 6, e1642, Feb *corresponding author (IF=6.30)
Alan Yueh-Luen Lee, CC Fan, YA Chen, CW Cheng, YJ Sung, CP Hsu, TY Kao*. (2015) Curcumin inhibits invasiveness and epithelial-mesenchymal transition in oral squamous cell carcinoma through reducing matrix metalloproteinase 2, 9 and modulating p53-E-cadherin pathway. Integrative Cancer Therapies 14(5): 484-490, Sep (IF=2.38; R/C= 9/28, INTEGRATIVE and COMPLEMENTARY MEDICINE )
Jui-Ling Tsai, Yu-May Lee, Chien-Yuan Pan, Alan Yueh-Luen Lee* (2016) The novel VEGF121-VEGF165 fusion attenuates angiogenesis and drug resistance via targeting VEGFR2-HIF-1α-VEGF165/Lon signaling through PI3K-AKT-mTOR pathway. Current Cancer Drug Targets 16(3):275-86 *corresponding author (IF=2.91; R/C= 141/244, ONCOLOGY)
CW Cheng#, JR Hsiao#, CC Fan#, YK Lo, CY Tzen, LW Wu, WY Fang, AJ Cheng, CH Chen, SS Jiang , IS Chang, JY Chang, and Alan Yueh-Luen Lee*. (2016) Loss of GDF10/BMP3b as a prognostic marker collaborates with TGFBR3 to enhance chemotherapy resistance and epithelial-mesenchymal transition in oral squamous cell carcinoma. Molecular Carcinogenesis 55(5):499-513 *corresponding author (IF=3.82)
AN Cheng#, CC Fan#, YK Lo, CL Kuo, HC Wang, SY Lin, CH Chen, SS Jiang, IS Chang, HF Juan, PC Lyu, and Alan Yueh-Luen Lee*. (2017) Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer. Scientific Reports 7: 17024 *corresponding author (IF=3.99; R/C= 17/71, MULTIDISCIPLINARY SCIENCES)
YJ Sung#, TY Kao#, CL Kuo# , CC Fan, AN Cheng, WC Fang, HY Chou, YK Lo, CH Chen, SSJiang, IS Chang, CH Hsu, JC Lee, and Alan Yueh-Luen Lee*. (2018) Mitochondrial Lon sequesters and stabilizes p53 in the matrix to restrain apoptosis under oxidative stress via its chaperone activity. Cell Death and Disease 9(6): 697 *corresponding author (IF=6.30; R/C= 40/195, CELL BIOLOGY)
L-C Cheng, Y-L Chen, A-N Cheng, Alan Yueh-Luen Lee, C-Y Cho, J-S Huang, S-E Chuang. (2018) AXL phosphorylates and up-regulates TNS2 and its implication in IRS1-associated metabolism in cancer cells. Journal of Biomedical Science 25(1):80
C-H Lu, D-W Yeh, C-Y Lai, Y-L Liu, L-R Huang, Alan Yueh-Luen Lee, S.-L. C. Jin & T-H Chuang. (2018) USP17 mediates macrophage-promoted inflammation and stemness in lung cancer cells by regulating TRAF2/TRAF3 complex formation. Oncogene 37(49):6327-6340
An Ning Cheng#, Yu-Kang Lo#, Yi-Sheng Lin, Tswen-Kei Tang, Chun-Hua Hsu, John T.-A. Hsu, and Alan Yueh-Luen Lee*. (2018) Identification of novel Cdc7 kinase inhibitors as anti-cancer agents that target the interaction with Dbf4 by the fragment complementation and drug repositioning approach. EBioMedicine 36: 241-251 *corresponding author (IF=5.73; R/C=18/139, MEDICINE, RESEARCH & EXPERIMENTAL) Commentary: A new screening method for ATP-independent kinase inhibitors identifies repurposed anti-cancer drugs. https://www.ebiomedicine.com/article/S2352-3964(18)30431-6/fulltext
P Wang, J Deng, J Dong, J Liu, EH. Bigio, M. Mesulam, T Wang, L Sun, L Wang, Alan Yueh-Luen Lee, W McGee, X Chen, K Fushimi, L Zhu, Jane Y Wu. (2019) TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response. PLOS Genetics 15(5):e1007947
CC Fan*, CH Chen, C Chou, TY Kao, AN Cheng, Alan Yueh-Luen Lee*, CL Kuo* (2020). A time-saving modified Giemsa stain is a better diagnostic method of Helicobacter pylori infection compared with the rapid urease test. Journal of Clinical Laboratory Analysis 34(4): e23110 *corresponding author
CL Kuo, HY Chou, YC Chiu, AN Cheng, CC Fan, YN Chang, CH Chen, SS Jiang, NJ Chen, and Alan Yueh-Luen Lee*. (2020) Mitochondrial oxidative stress by Lon-PYCR1 maintains an immunosuppressive tumor microenvironment that promotes cancer progression and metastasis. Cancer Letters 474(1): 138-150 *corresponding author (IF=7.36; R/C= 30/244, ONCOLOGY)
AN Cheng, LC Cheng, CL Kuo, YK Lo, HY Chou, CH Chen, YH Wang, TH Chuang, SJ Cheng , and Alan Yueh-Luen Lee*. (2020) Mitochondrial Lon-induced mtDNA leakage contributes to PD-L1-mediated immunoescape via STING-IFN signaling and extracellular vesicles. Journal for ImmunoTherapy of Cancer 8(2): e001372 *corresponding author (IF=10.25; R/C= 16/244, ONCOLOGY；R/C= 10/159, IMMUNOLOGY)
Semon Wu*, I-C Tseng, W-C Huang, C-W Su, Y-H Lai, C Lin, Alan Yueh-Luen Lee, C-Y Kuo, L-Y Su, M-C Lee, T-C Hsu, and C-H Yu. (2020) Establishment of an immunocompetent metastasis rat model with hepatocyte cancer stem cells. Cancers 12: 3721 (IF=6.12)
SH Liu*, PS Chen, CC Huang, YT Hung, MY Lee, WH Lin, YC Lin, and Alan Yueh-Luen Lee* (2021) Unlocking the mystery of the therapeutic effects of Chinese medicine on cancer. Frontiers in Pharmacology 11:601785 *corresponding author (IF=4.22)
H-Y Chou, L-H Liu, C-Y Chen, I-F Lin, Daoud Ali, Alan Yueh-Luen Lee*, H-M David Wang*. (2021) Bifunctional mechanisms of autophagy and apoptosis regulations in melanoma from Bacillus subtilis natto fermentation extract. Food and Chemical Toxicology 150:112020. *corresponding author (IF=4.68)
YW Lo, Alan Yueh-Luen Lee, YC Liu, HH Ko, HH Peng, HC Lee, PY Pan, CP Chiang, Shih-Jung Cheng. (2021)β-glucan therapy converts the inhibition of myeloid-derived suppressor cells in oral cancer patients. Oral Diseases (In press)
J-C Tseng , J-X Yang, Y-L Liu, Y-W Su, Alan Yueh-Luen Lee, Y-W Chen, K-J Liu, Yunping Luo, Y-R Hong, T-H Chuang* (2021) Sharpening up tumor microenvironment to enhance the efficacy of immune checkpoint blockade on head and neck cancer using a CpG-oligodeoxynucleotide. Cancer Immunology, Immunotherapy (In press) (IF=5.44)
V Tangeda, Y-K Lo, AP Babuharisankar, H-Y Chou, C-L Kuo, Y-H Kao*, Alan Yueh-Luen Lee* and J-Y Chang*. (2022) Lon upregulation contributes to cisplatin resistance by triggering NCLX-mediated mitochondrial Ca2+ release in cancer cells. Cell Death and Disease (In press) *corresponding author
CL Kuo1#, HY Chou#, HW Lien, CA Yeh, JR Wang, CH Chen, CC Fan, CP Hsu, TY Kao, TM Ko, and Alan Yueh-Luen Lee* (2022) A Fc-VEGF chimeric fusion enhances PD-L1 immunotherapy via inducing immune reprogamming and infiltration in the immunosuppressive tumor microenvironment. (In Submission)
B. INVITED SPEAKER
Alan Yueh-Luen Lee. Role of Mitochondrial Lon in Promoting Epithelial-Mesenchymal Transition and Angiogenesis under Hypoxic Tumor Microenvironment. The 67th Annual Meeting of the Japan Society for Cell Biology. Tokyo, Japan, June 30- July 2, 2015.
Alan Yueh-Luen Lee. (Session 02-2) 2015 Taiwan Society for Mitochondrial Research and Medicine annual meeting & symposium on mitochondrial dysfunction in human diseases. Taipei, Taiwan, December 5, 2015.
Invited as Taiwan Academic Panelist. The 2016 Boston Taiwanese of Biotechnology Association (BTBA) symposium. Boston, USA, July 16-17, 2016.
Alan Yueh-Luen Lee. Mitochondrial Lon Promotes Epithelial-Mesenchymal Transition and Angiogenesis under Hypoxia via ROS-mediated Signaling. (Session C1-1). 4th International Symposium of Australasian College of Medical Sciences and Research & 2016 Annual Meeting of Taiwan Society for Mitochondrial Research and Medicine. Changhua, Taiwan, September 24-25, 2016
Alan Yueh-Luen Lee. Mitochondrial Stress Promotes Cancer Metastasis via ROS-p38/NF-κB Inflammation Pathways. (Session 1). International Conference on Recent Advances in Inflammation 2016. Tainan, Taiwan, November 11-12, 2016
Alan Yueh-Luen Lee. Mitochondrial Lon-mediated survival responses to oxidative stress in tumor microenvironment. (Talk 6). 2017 Mini Symposium on Mitochondrial Structure and Function, Lecture Hall, ICOB, Academia Sinica, Taipei Taiwan, October 23, 2017
Alan Yueh-Luen Lee. The survival response to mitochondrial stress in tumor microenvironment: From mechanism to cancer therapy. (Session S03-3). 2017 Annual Meeting of Taiwan Society for Mitochondrial Research and Medicine. Kaohsiung, Taiwan, November 4, 2017
Alan Yueh-Luen Lee. The survival response to mitochondrial oxidative stress endues tumorigeneity in tumor microenvironment. (Mitochondrial Medicine Section). The 33rd Joint Annual Conference of Biomedical Science-The Taiwan Society for Biochemistry and Molecular Biology. Taipei, Taiwan, March 24, 2018
The survival response to mitochondrial oxidative stress endues tumorigenicity in tumor microenvironment. Department of Life Sciences, National Central University, Chongli, Taiwan, May 22, 2018
The survival response to mitochondrial stress endues tumorigenicity via affecting tumor microenvironment. School of Life Sciences, Special Lectures on Biomedicine, National Yang-Ming University, Taipei, Taiwan, September 19, 2018
Mitochondrial oxidative stress induces cancer immunoescape via mtDNA-mediated Inflammation in tumor microenvironment. Mini-symposium of Mitochondrial Medicine & Research, National Chung Hsing University, Taichung, Taiwan, April 23, 2019. As a Chair of session 4 in the 9th International Symposium on Autophagy, Session 4: Mechanism of autophagy, 3, November 3-7, 2019 in Taipei, Taiwan. (受邀於中研院舉行之第九屆細胞自嗜國際研討會擔任演講主持人)
「The resistance to cancer immunotherapy through mitochondria-mediated inflammation: therapeutic application of vascular normalizing strategy」, 2020 NHRI-NCU Joint Research conference, National Central University, Chongli, Taiwan, Nov. 6, 2020 (2020國衛院-中央大學生科院聯合學術研討會)
