Medical Oncology, Cancer pharmacology and drug discovery
Dr. Chang’s research interests focus on two areas: (1) identify the risk factors of chemotherapy-induced peripheral neuropathy; (2) discover neuroprotective compounds to against chemotherapy-induced peripheral neuropathy.
RESEARCH ACTIVITIES & ACCOMPLISHMENT
With the cooperation with Institute of Biotechnology and Pharmaceutical Research, we have identified candidate lead compounds to protect paclitaxel- and oxaliplatin-induced peripheral neuropathy. Preclinical pharmacological studies are ongoing. In addition, we focus on studying the neuroprotective role of protease inhibitor in different animal models.