蔡慧珍 助研究員級主治醫師-論文

PUBLICATIONS
  1. Chang JS, Chen LT, Shan YS, Chu PY, Tsai CR , Tsai HJ. The incidence and survival of pancreatic cancer by histology, including rare subtypes: a nation-wide cancer registry-based study from Taiwan. Cancer Medicine. 2018 Sep 27. doi: 10.1002/cam4.1795. [Epub ahead of print] (IF:3.202,Journal ranking:Oncology : 110/222 (Q2)) (通訊作者)
  2. Tsai HJ, Jiaang WT, Shih NY, Fletcher JA, Lin MJ, Yang MY, Chen CT, Hsu TA, Wu CC, Lin HY, Chen LT. BPR1J373, a novel multi-targeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor. Cancer Science Aug 24. doi: 10.1111/cas.13773. [Epub ahead of print] (IF:4.372,Journal ranking:Oncology : 65/222 (Q2))( 第一作者&通訊作者)
  3. Hsu YT, Tsai HJ, Chang JS, Li SS, Tang JL, Yeh SP, Hwang WL, Liu JH, Tan TD, Wang PN, Hsiao HH, Chen TY. Stem cell transplantation for T-cell lymphomas in Taiwan. Bone Marrow Transplant. 2018 Feb 12. doi: 10.1038/s41409-018-0116-6. [Epub ahead of print] (IF:4.497,Journal ranking: Transplantation: 5/25 (Q1))(共同作者)
  4. Chu PY*, Jiang SS*, Shan YS*, Hung WC, Chen MH, Lin HY, Chen YL, Tsai HJ, Chen LT. Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) regulates the cell metabolism of pancreatic neuroendocrine tumors (pNET) and de-sensitizes pNET to mTOR inhibitors. Oncotarget  2017;8(61):103613-103625.  (通訊作者)
  5.  Chang TM*, Shan YS*, Chu PY*, Jiang SS, Hung WC, Chen YL, Tu HC, Lin HY, Tsai HJ, Chen LT. The regulatory role of aberrant Phosphatase and Tensin Homologue and Liver Kinase B1 on AKT/mTOR/c-Myc axis in pancreatic neuroendocrine tumors. Oncotarget   2017;8(58):98068-98083.  (通訊作者)
  6. Tsai HJ, Jiang SS, Hung WC, Borthakur G, Lin SF, Pemmaraju N, Jabbour E, Bomalaski JS, Chen YP, Hsiao HH, Wang MC, Kuo CY, Chang H, Yeh SP, Cortes J, Chen LT, Chen TY. A phase II study of arginine deiminase (ADI-PEG20) in relapsed/refractory or poor-risk acute myeloid leukemia patients. Sci Rep.  2017 Sep 12;7(1):11253. (IF:4.259,Journal ranking: MULTIDISCIPLINARY SCIENCES: 10/64(Q1))(第一作者)
  7.  Kuo SH, Tsai HJ, Lin CW, Yeh KH, Lee HW, Wei MF, Shun CT, Wu MS, Hsu PN, Chen LT, Cheng AL. B cell-activating factor signalling pathway is associated with H. pylori independence in gastric MALT lymphoma without t(11;18)(q21;q21). J Pathol. 2017 Feb;241(3):420-433.  (IF:6.894,Journal ranking: Oncology: 22/217(Q1))(共同作者)
  8. Chen LT, Chen CT, Jiaang WT, Chen TY, Butterfield JH, Shih NY, Hsu JT, Lin HY, Lin SF, Tsai HJ. BPR1J373, an oral multiple tyrosine kinase inhibitor, targets c-KIT for the treatment of c-KIT driven myeloid leukemia. Mol Cancer Ther 2016;15:2323-2333. (IF:5.764,Journal ranking: Oncology: 36/217(Q1))(通訊作者)
  9.  Chen JY, Lai YS, Tsai HJ, Kuo CC, Yen BL, Yeh SP, Sun HS, Hung WC. The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells. Sci Rep 2016;6:32428. (IF:4.259,Journal ranking: MULTIDISCIPLINARY SCIENCES: 10/64(Q1))(共同作者)
  10. Chang JS, Chen LT, Shan YS, Lin SF, Hsiao SY, Tsai CR, Yu SJ, Tsai HJ. A comprehensive analysis in the incidence and survival patterns of lung cancer by histologies, including rare subtypes, in the era of molecular medicine and targeted therapy: a nation-wide cancer registry-based study from Taiwan. Medicine 2015,  Jun;94(24):e969. (IF:2.133,Journal ranking: Medicine, General & Internal: 40/153(Q2))(通訊作者)
  11. Kuo SH, Yeh KH, Chen LT, Lin CW, Hsu PN, Wu MS, Liou JM, Tsai HJ, Tzeng YS, Cheng AL. Helicobacter pylori CagA Translocation Is Closely Associated With the Expression of CagA-signaling Molecules in Low-grade Gastric Mucosa-associated Lymphoid Tissue Lymphoma. Am J Surg Pathol. 2015 Jun;39(6):761-6.
  12. Lai YS, Chen JY, Tsai HJ, Chen TY, Hung WC. The SUV39H1 inhibitor chaetocin induces differentiation and shows synergistic cytotoxicity with other epigenetic drugs in acute myeloid leukemia cells. Blood Cancer Journal 2015;5:e313.
  13. Tsai HJ, Shih NY, Kuo SH, Cheng AL, Lin HY, Chen TY, Chang KC, Lin SF, Chang JS, Chen LT. AUY922 Effectively Targets against ABC-DLBCL and MALT Lymphoma Cells Harboring Genetic Alteration-Associated NF-κB Activation. Leuekmia Lymphoma 2015 Sep;56(9):2674-82..
  14. Hsiao HH, Liu YC, Wang HC, Wu CH, Cho SF, Hsu JF, Tsai HJ, Hsiao SY, Chang CS, Lin SF, Liu TC, Chuang WL, Yu ML. Hepatitis C transmission from viremic donors in hematopoietic stem cell transplant. Transpl Infect Dis. 2014 Dec;16(6):1003-6
  15. Tsai HJ, Lin SF, Chen CC, Chen TY, Su WC, Hwang WL, Lin JC, Chiou TJ, Kao WY, Chiu CF, Chang YF, Chang JS, Chang MC, Su IJ. Long term results of a phase II trial with front-line concurrent chemoradiotherapy followed by consolidation chemotherapy for localized nasal natural killer/T-cell lymphoma. European Journal of Haematology 2015 Feb;94(2):130-7.
  16. Kuo SH, Yeh KH, Chen LT, Lin CW, Hsu PN, Hsu C, Wu MS, Tzeng YS, Tsai HJ, Wang HP, Cheng AL. Helicobacter pylori-related diffuse large B-cell lymphoma of the stomach: a distinct entity with lower aggressiveness and higher chemosensitivity. Blood Cancer J 2014 Jun 20;4:e220.
  17. Tsai HJ, Wu CC, Tsai CR, Lin SF, Chen LT, Chang JS. Second Cancers in Patients with Neuroendocrine Tumors. PLOS ONE 2013;Dec 31;8(12):e86414.
  18. Kuo SH†, Tsai HJ†, Weng WH, Li CC, Yeh KH, Chen LT, Cheng AL. Beware imposters: MA-1, a novel MALT lymphoma cell line, is misidentified and corresponds to Pfeiffer, a diffuse large B-cell lymphoma cell line-A reply: Despite the same 8-code STR, MA-1 and Pfeiffer are cytogenetically diverse. Genes Chromosomes Cancer. 2014 Feb;53(2):211-3. (†eaqual contribution)
  19. Kuo SH, Chen LT, Lin CW, Wu MS, Hsu PN, Tsai HJ, Chu CY, Tzeng YS, Wang HP, Yeh KH, Cheng AL. Detection of the Helicobacter pylori CagA protein in gastric mucosa-associated lymphoid tissue lymphoma cells: clinical and biological significance. Blood Cancer J. 2013 Jul 12;3:e125. doi: 10.1038/bcj.2013.22.
  20. Tsai HJ, Wu CC, Tsai CR, Lin SF, Chen LT, Chang JS. The Epidemiology of Neuroendocrine Tumors in Taiwan: a Nation-wide Registry-based Study. PLOS ONE 2013;Apr 22;8(4):e62487
  21. Hsu YL, Tsai HJ, Chen YW, Lin CY, Lee CS, Chang CC. High metabolic lymphoma of the masticator space on FDG PET/CT image. Annals of Nuclear Medicine and Molecular Imaging 2011;24:144-145
  22. Tsai HJ, Kobayashi S, Izawa K, Ishida T, Umezawa K, Lin SF, Tojo A. Bioimaging analysis of nuclear factor-kB activity in Philadelphia chromosome-positive acute lymphoblastic leukemia cells reveals its synergistic upregulation by tumor necrosis factor-a-stimulated changes to the microenvironment. Cancer Sci 2011;102:2014-21
  23. Kuo SH, Weng WH, Chen ZH, Hsu PN, Wu MS, Lin CW, Jeng HJ, Yeh KH, Tsai HJ, Chen LT, Cheng AL. Establishment of a novel MALT lymphoma cell line, ma-1, from a patient with t(14;18)(q32;q21)-positive Helicobacter Pylori-Independent Gastric MALT Lymphoma. Genes Chromosomes Cancer. 2011;50:908-21
  24. Cho SF, Liu YC, Tsai HJ, Lin SF. Myeloid Sarcoma Mimicking Nasopharyngeal Carcinoma. J Clin Oncol. 2011;29:e706-8.
  25. Yang MY, Yang WC, Lin PM, Hsu JF, Hsiao HH, Liu YC, Tsai HJ, Chang CS, Lin SF. Altered expression of circadian clock genes in human chronic myeloid leukemia. J Biol Rhythms. 2011;26:136-148
  26. Hsiao HH, Liu YC, Tsai HJ, Hsu JF, Yang WC, Chang CS, Lin SF. Additional chromosome abnormalities in chronic myeloid leukemia. Kaohsiung J Med Sci. 2011;27:49-54
  27. Hsiao HH, Liu YC, Tsai HJ, Lee CP, Hsu JF, Lin SF. JAK2V617F mutation is associated with special alleles in essential thrombocythemia. Leuk Lymphoma. 2011 Mar;52(3):478-82. Epub 2011 Feb 1
  28. Li CP, Chen JS, Chen LT, Yen CJ, Lee KD, Su WP, Lin PC, Lu CH, Tsai HJ, Chao Y. A phase II study of weekly docetaxel and cisplatin plus oral tegafur/uracil and leucovorin as first-line chemotherapy in patients with locally advanced or metastatic gastric cancer. Br J Cancer. 2010 Oct 26;103(9):1343-8
  29. Tai SY, Wu IC, Wu DC, Su HJ, Huang JL, Tsai HJ, Lu CY, Lee JM, Wu MT. Cigarette smoking and alcohol drinking and esophageal cancer risk in Taiwanese women. World J Gastroenterol. 2010 Mar 28;16(12):1518-21
  30. Wu IC, Wu DC, Huang CC, Lin HS, Chen YK, Tsai HJ, Lu CY, Chou SH, Chou YP, Li LH, Tai SY, Wu MT. Plasma decorin predicts the presence of esophageal squamous cell carcinoma. Int J Cancer. 2010;127:2138-46
  31. Hsiao HH, Tsai HJ, Liu YC, Lee CP, Lin SF. Allo-SCT in a rare t(8;21) evolution of CML. Bone Marrow Transplant 2010;45:1365-6.
  32. Liu YC, Lu PL, Hsiao HH, Tsai HJ, Liu TC, Lin SF. Herpes zoster infection associated with poor peripheral blood hematopoietic stem cell mobilization. J Formos Med Assoc. 2008 Dec;107(12):958-60
  33. Liu YC, Hsiao HH, Chang JG, Yang MY, Liu TC, Chang CS, Tseng SB, Tsai HJ, Lin SF. Usefulness of quantitative assessment of JunB gene expression as a marker for monitoring chronic myeloid leukemia patients undergoing imatinib therapy. Int J Hematol. 2006 Dec;84(5):425-31
  34. Hsiao HH, Liu YC, Tsai HJ, Chen LT, Lee CP, Chuan CH, Wang JY, Yang SF, Tseng YT, Lin SF. Imatinib mesylate therapy in advanced gastrointestinal stromal tumors: experience from a single institute. Kaohsiung J Med Sci. 2006 Dec;22(12):599-603
  35. Chen SC, Tsai HJ, Jan CM, Wang YH, Chen LT. Low dose of thalidomide can be effective in advanced hepatocellular carcinoma. J Gastroenterol Hepatol. 2006 Dec;21(12):1868-9
  36. Hsiao HH, Tsai HJ, Liu YC, Tseng YT, Tseng SB, Chai CY, Lin SF. A rare case of combined small-cell lung cancer with unusual soft tissue metastasis. Kaohsiung J Med Sci 2006 Jul;22(7):352-6
  37. Hsiao HH, Tsai HJ, Liu YC, Tseng YT, Lu PL, Yang WC, Liu TC, Lin SF. Invasive Fungal Infection in Patients with Acute Leukemia. Kaohsiung J Med Sci 2006 May;22(5):217-22
  38. Hu SW, Lin WC, Tsai HJ, Chien SH, Tsai KB. Immunoprofiles in malignant peripheral nerve sheath tumor: three case reports and literature review. Kaohsiung J Med Sci. 2006 Mar;22(3):135-42
  39. Hsiao HH, Liu YC, Tsai HJ, Tsai KB, Cheng YJ, Chou SH, Chong IW, Yang WC, Liu TC, Lin SF. Poor outcomes in patients with primary malignant mediastinal germ-cell tumors. Kaohsiung J Med Sci 2005:21:561-5
  40. Hsiao HH, Hung YH, Hsiao HP, Tseng SB, Tsai HJ, Liu YC, Liu TC, Chao MC, Chang Y, Lin SF. Case of chronic lymphocytic leukemia with unusual chromosome aberrations. Int J Hematol. 2004 Nov;80(4):351-3
  41. Tsai HJ, Lin SF, Liu TC, Chang CS, Hsiao HH, Chen TP. Pure red cell aplasia after ABO major-mismatched allogeneic peripheral blood stem cell transplantation successfully treated with plasma exchange  and low-dose steroid: two case reports. Kaohsiung J Med Sci. 2004 Mar;20(3):128-32
  42. Tseng SB, Lin SF, Chang CS, Liu TC, Hsiao HH, Liu YC, Tsai HJ, Chen TP. Successful treatment of acquired pure red cell aplasia (PRCA) by allogeneic peripheral blood stem cell transplantation. Am J Hematol. 2003 Dec;74(4):273-5
  43. Chen TP, Liu TC, Chang CS, Chang JG, Tsai HJ, Lin SF. PCR-based analysis of alpha-thalassemia in Southern Taiwan. Int J Hematol. 2002 Apr;75(3):277-80
CONFERENCES
  1. Tsai HJ, Chang JS, Shan YS, Tsai CR, Chen LT. The epidemiology of gastric cancer in the era of H. pylori eradication: a nation-wide registry-based study in Taiwan. (poster) The 77th Annual Meeting of the Japancese Cancer Association. Sep 27-29, 2018, Osaka, Japan.
  2.  Tsai HJ. The epidemiologic trend in NETs (invited speaker) The 11th International Pancreatic Cancer Conference, Commemorative Lecture of Pin-Wen Lin and 2018 Cancer Biology Symposium. 2018, Jun 8-10, Tainan, Taiwan.
  3. Tsai HJ, Chu PY, Jiang SS, Shan YS, , Hung WC, Chen MH, Lin HY, Chen YL, Chen LT. The role of aberrant mitochondrial phosphoenolpyruvate carboxykinase expression in pancreatic neuroendocrine tumors. (oral presentation) The 76th Annual Meeting of the Japancese Cancer Association. Sep 28-30, 2017, Yokohama, Japan.
  4. Tsai HJ, Tsai CR, Chang JS. A comprehensive analysis in the incidence and survival of pancreatic cancer by histology, including rare subtypes: a nation-wide cancer registry-based study from Taiwan. (Poster) The 21th International Epidemiological Association (IEA) World Congress of Epidemiology (WCE 2017). Aug 19-22, 2017. Saitama, Japan.
  5. Tsai HJ, Chang TM, Shan YS, Chu PY, Jiang SS, Hung WC, Chen YL, Tu HC, Chen LT. The regulatory role of PTEN and LKB1 on mTOR pathway in pancreatic neuroendocrien tumors. (Poster) The 49th Meeting of European Pancreatic Club. 2017 Jun 28-Jul 1. Budapest, Hungary.
  6. Tsai HJ. The role of expression of PTEN and LKB1 in pNET. (Invited speaker) The 10th International Pancreatic Cancer Conference, Commemorative Lecture of Pin-Wen Lin and 2017 Cancer Biology Symposium. 2017, Jun 23-25, Tainan, Taiwan.
  7.  Tsai HJ. National Survey of GEP-NETs in Taiwan. (Invited speaker) 2nd Annual Meeting of the Digestive Endoscopy Society of Taiwan in 2016 (DEST 2016). 2016, Aug 6, Taipei. (台大國際會議廳)
  8. Tsai HJ, Jiaang WT, Chen CT, Hsu TA, Lin HY, Kobayashi S, Tojo A, Chen LT. Novel multi-targeted agent against Philadelphia chromosome positive acute lymphoblastic leukemia. (poster) The 77th annual meeting of Japanese Society of Hematology 2015, Oct 16-18, Kanazawa, Japan
  9. Tsai HJ, Chen LT, Shan YS, Lin SF, Hsiao SY, Tsai CR , Yu SJ, Chang JS. The changing incidence and survival of lung cancer in the era of targeted therapy: a nation-wide study from Taiwan. (poster) the 74th annual meeting of Japanese Cancer Association 2015, Oct 8-10, Nagoya, Japan.
  10. Tsai HJ, Jiang WT, Chen CT, Hsu TA, Lin HY, Lin SF, Chen TY, Chen LT. Promising Novel Targeted Agent against c-KIT Driven Acute Myeloid Leukemia. 中華民國血液病學會暨中華民國血液及骨髓移植學會104年度聯合學術年會. Apr 18, 2015 at 台大國際會議廳(oral presentation)
  11. Tsai HJ, Wang MC, Lin SF, Chen YP, Hsiao HH, Kuo CY, Chen LT, Chen TY. Pegylated arginine deiminase (ADI-PEG20) in relapsed/refractory and/or elder acute myeloid leukemia: the preliminary result of phase II trial. (Poster) The 56th annual meeting of American Society of Hematology Dec 6-9, 2014 at San Francisco, US.
  12. Tsai HJ, Lin MJ, Jiang WT, Chen CT, Hsu TA, , Lin HY, Chen LT. BPR1J373, a novel multi-targeted tyrosine kinase inhibitor, effectively inhibits the growth of gastrointestinal stromal tumor in vitro and in vivo. The 73th annual meeting of Japanese Cancer Association. (oral presentation, travel award). Sep 25-27, 2014 at Yokohama, Japan.
  13. Tsai HJ. The epidemiology of neuroendocrine tumors in Taiwan. (invited speaker)國際胰臟惡性腫瘤研討會2014, Nov22, at 林口長庚紀念醫院.
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