劉柯俊 研究員-論文

PUBLICATIONS
  1. L.-T. Wang, S.-S. Jiang, C.-H. Ting, P.-J. Hsu, C.-C. Chang, H.-K. Sytwu1, K.-J. Liu, B. L. Yen. Differentiation of MSCs from human iPSCs results in downregulation of c-Myc & DNA replication pathways with immunomodulation towards CD4 & CD8 cells. Stem Cells. 36(6):903-914. 2018.
  2. S.-J. Leu, Y.-Y. Yang, H.-C. Liu, C.-Y. Cheng, Y.-C. Wu, M.-C. Huang, Y.-L. Lee,  C.-C. Chen, W. W. Shen, K.-J. Liu*.   Valproic acid and lithium meditate anti-inflammatory effects by differentially modulating dendritic cell differentiation and function.  Journal of Cellular Physiology. 232:1176-1186. 2017. (SCI 2015 IF=4.155, Journal ranking: Physiology: 12/83=14.5%) (*corresponding author)
  3. K.-J. Liu*, T.-Y. Chao, J.-Y. Chang, A.-L. Cheng, H.-J. Ch’ang, W.-Y. Kao, Y.-C. Wu, W.-L. Yu, T.-R. Chung, and J. Whang-Peng*.  A phase I clinical study of immunotherapy for advanced colorectal cancers using carcinoembryonic antigen-pulsed dendritic cells mixed with tetanus toxoid and subsequent IL-2 treatment.  Journal of Biomedical Science.  23:64-74. 2016. (SCI 2015 IF=2.935, Journal ranking: Medicine, Research and Experimental: 45/124=36.3%) (*corresponding author)
  4. L.-T. Wang, C.-H. Ting, M.-L. Yen, K.-J. Liu, H.-K. Sytwu, Kenneth K. Wu, and B. L Yen. Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials.  Journal of Biomedical Science.  23:76-88. 2016. (SCI 2015 IF=2.935, Journal ranking: Medicine, Research and Experimental: 45/124=36.3%)
  5. K.-C. Hsiao, N.-Y. Shih, P.-Y. Chu, Y.-M. Hung, J.-Y. Liao, S.-W. Chou, Y.-Y. Yang, G.-C. Chang*, K.-J. Liu*.  Anti-α-enolase is a prognostic marker in postoperative lung cancer patients.  Oncotarget. 6(33):35073-35086.  2015. (SCI 2015 IF=5.008, Journal ranking: Oncology: 36/213=16.9%) (*co-corresponding author)
  6. C.-H. Lee, S.-H. Syu, K.-J. Liu, P.-Y. Chu, W.-C. Yang, P. Lin, W.-Y. Shieh.  Interleukin-1 beta transactivates epidermal growth factor receptor via the CXCL1-CXCR2 axis in oral cancer.  Oncotarget. 6(36):38866-38880. 2015. (SCI 2015 IF=5.008, Journal ranking: Oncology: 36/213=16.9%)
  7. W.-B. Wang, M.-L. Yen, K.-J. Liu*, P.-J. Hsu, M.-H. Lin, P.-M. Chen, P.-R. Sudhir, C.-H. Chen, C.-H. Chen, H.-K. Sytwu, B. L. Yen*.  Interleukin-25 mediates transcriptional control of PD-L1 through STAT3 in multipotent human mesenchymal stromal cells (hMSCs) to suppress Th17 responses.  Stem Cell Reports. 5(3):392-404. 2015.  (SCI 2014 IF=5.365, Journal ranking: Cell & Tissue Engineering: 4/21=19%) (*co-corresponding author)
  8. P.-J. Hsu, K.-J.  Liu, H.-K. Sytwu, B. L. Yen. Assessment of the immunomodulatory properties of human mesenchymal stem cells (MSCs).  Journal of Visualized Experiments. 106:e53265. 2015.  (SCI 2014 IF=1.325, Journal ranking: Multidisciplinary Sciences: 16/56=28.6%)
  9. C.-H.  Yang, H.-C. Chou, Y.-N. Fu, C.-L. Yeh, H.-W. Cheng, I.-C.  Chang, K.-J.  Liu, G.-C. Chang, T.-F. Tsai, S.-F.  Tsai, H.-P.  Liu, Y.-C.  Wu, Y.-T. Chen, S.-F. Huang, Y.-R Chen, EGFR over-expression in non-small cell lung cancers harboring EGFR mutations is associated with marked down-regulation of CD82. BBA-Molecular Basis of Disease. 1852(7):1540-1549. 2015. (SCI 2014 IF=4.882, Journal ranking: Biochemistry & Molecular Biology: 54/289=18.7%)
  10. L.-H. Hsu, K.-J. Liu, M.-F. Tsai, C.-R. Wu, A.-C. Feng, N.-M. Chu, S.-H. Kao. Estrogen adversely affects the prognosis of patients with lung adenocarcinoma.  Cancer Science. 106(1):51-59. 2015. (SCI 2014 IF=3.523, Journal ranking: Oncology: 72/211=34.1%)
  11. C.-H. Lee*, S.-H. Syu, T.-S. Wong, J. Y.-W Chan, Y.-C. Tang, Z.-P. Yang, J. S.-M. Chang, W.-C. Yang, C.-T. Chen, S.-C. Lu, P.-H. Tang, T.-C. Yang,  P.-Y. Chu, J.-R. Hsiao, and K.-J. Liu*. (*co-corresponding author)  IL-1β promotes malignant transformation and tumor aggressiveness in oral cancer.  Journal of Cellular Physiology. 230:875-884. 2015. (SCI 2014 IF=3.839, Journal ranking: Physiology: 15/83=18.1%)
  12. P.-M. Chen, K.-J. Liu, P.-J. Hsu, C.-F. Wei, C.-H. Bai, L.-J. Ho, H.-K. Sytwu, and B. L. Yen.  Induction of immunomodulatory monocytes by human mesenchymal stem cell-derived hepatocyte growth factor through ERK1/2.  Journal of Leukocyte Biology.  2014. jlb.3A0513-242R; doi:10.1189/jlb.3A0513-242R (SCI 2014 IF=4.289, Journal ranking: Immunology, 31/148=20.9%)
  13. C.-C. Chen, L.-L. Chen, Y.-T. Hsu, K.-J. Liu, C.-S. Fan, and T.-S. Huang. The Endothelin-Integrin Axis is Involved in Macrophage-Induced Breast Cancer Cell Chemotactic Interactions with Endothelial Cells.  Journal of Biological Chemistry. 289(14):10029-10044. 2014. (SCI 2014 IF=4.573, Journal ranking: Biochemistry & Molecular Biology: 61/290=21.0%)
  14. T.-E. Hua, T.-L. Yang, W.-C. Yang, K.-J. Liu* and S.-C. Tang*. (*co-corresponding author) 3-D neurohistology of transparent tongue in health and injury with optical clearing.  Frontiers in Neuroanatomy. 7:36. doi: 11.3389/fnana.2013.00036. 2013. (SCI 2014 IF=3.544, Journal ranking: Anatomy & Morphology: 3/20=15.0%)
  15. K.-C. Hsiao, N.-Y. Shih, H.-L. Fang, T.-S. Huang, C.-C. Kuo, P.-Y. Chu, Y.-M. Hung, S.-W. Chou, Y.-Y Yang, G.-C. Chang*, K.-J. Liu*. (*co-corresponding author)  Surface α-Enolase Promotes Extracellular Matrix Degradation and Tumor Metastasis and Represents a New Therapeutic Target.  PLOS ONE.  8(7): e69354. doi:10.1371/journal.pone.0069354. 2013. (SCI 2014 IF=3.234, Journal ranking: Multidisciplinary Sciences: 8/56=14.3%)
  16. C.-C. Chen, C.-B. Chu, K.-J. Liu, C.-Y. Huang, J.-Y. Chang, W.-Y. Pan, H.-H. Chen, Y.-H. Cheng, K.-D. Lee, M.-F. Chen, C.-C. Kuo, and L.-T. Chen.  Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: the role of IL-6 signaling and Nrf2/AKR1C axis identification.  Biochemical Pharmacology. 86(7):872-887.  2013. (SCI 2014 IF=5.009, Journal ranking: Pharmacology & Pharmacy:23/255=9.0%)
  17. B. L. Yen, M.-L. Yen, P.-J. Hsu. K.-J. Liu. C.-J. Wang. C.-H. Bai, H.-K. Sytwu.  Multipotent human mesenchymal stromal cells mediate the expansion of myeloid-derived suppressor cells through the HGF/c-met axis and STAT3.  Stem Cell Reports.  1(2):139-151. 2013.  (SCI 2014 IF=5.365, Journal ranking: Cell & Tissue Engineering: 4/21=19.0%)
  18. K.-Y. Chang, S.-Y. Tsai, S.-H. Chen, H.-H. Tsou, C.-J. Yen, K.-J. Liu, H.-L. Fang, H.-C. Wu, B.-F. Chuang, S.-W. Chou, C. K. Tang, S.-Y. Liu, P.-J. Lu, C.-Y. Yen and J.-Y. Chang.  Dissecting the EGFR-PI3K-AKT pathway in oral cancer highlights the role of the EGFR variant III and its clinical relevance.  Journal of Biomedical Science.  20:43-52. 2013. (SCI 2014 IF=2.763, Journal ranking: Medicine, Research and Experimental: 50/123=40.7%)
  19. C.-L. Chu, Y.-L. Yu, Y.-C. Kung, P.-Y. Liao, K.-J. Liu, Y.-T. Tseng, Y.-C. Lin, S. S.-Y. Hsieh, P. C.-S. Chong, C.-Y. Yang.   The immunomodulatory activity of meningococcal lipoprotein Ag473 depends on the conformation made up of the lipid and protein moieties.  PLOS ONE. 7(7): e40873. doi:10.1371/journal.pone.0040873. 2012. (SCI 2014 IF=3.234, Journal ranking: Multidisciplinary Sciences: 8/56=14.3%)
  20. K.-L. Chen, W.-S. Chang, C.-H. Cheung, C.-C. Lin, C.-C. Huang, Y.-N. Yang, C.-P. Kuo, C.-C. Kuo, Y.-H. Chang, K.-J. Liu, C.-M. Wu, and J.-Y. Chang. Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway. Cancer Letters. 317:89-98, 2012. (SCI 2014 IF=5.621, Journal ranking: Oncology: 24/211=11.4%)
  21. K.-J. Liu, C.-J. Wang, C.-J. Chang, H.-I. Hu, Y.-C. Wu, P.-J. Hsu, H.-K. Sytwu, and B. L. Yen. Surface expression of HLA-G is involved in mediating immunomodulatory effects of placenta-derived multipotent cells (PDMCs) towards natural killer lymphocytes.  Cell Transplantation. 20:1721-1730, 2011. (SCI 2014 IF=3.127, Journal ranking: Transplantation: 10/25=40%)
  22. K.-J. Liu*, Y.-L. Lee*, Y.-Y. Yang, N.-Y. Shih, C.-C. Ho, Y.-C. Wu, T.-S. Huang, M.-C. Huang, H.-C. Liu, W. W. Shen, and S.-J. Leu.  Modulation of the Development of Human Monocyte-Derived Dendritic Cells by Lithium Chloride.  Journal of Cellular Physiology. 226:424-433, 2011. (SCI 2014 IF=3.839, Journal ranking: Physiology: 15/83=18.1%) (*co-first author)
  23. C.-C. Lee, K.-J. Liu, S.-F. Yo, C.-C. Chang, and T.-S. Huang. Sesamin inhibits the angiogenic activity of macrophage-affected breast cancer cells via suppression of Cytokine-induced vascular endothelial growth factor and matrix metalloproteinase-9 expression.  Inflammation. 34(3):209-211, 2011. (SCI 2014 IF=2.208, Journal ranking: Immunology: 100/148=67.6%)
  24. P.-M. Chen, M.-L. Yen, K.-J. Liu, H.-K. Sytwu and B. L. Yen.  Immunomodulatory properties of human adult and fetal multipotent mesenchymal stem cells.  Journal of Biomedical Science. 18(1):49-59, 2011. (SCI 2014 IF=2.763, Journal ranking: Medicine, Research and Experimental: 50/123=40.7%)
  25. C.-C. Lin, · Y.-L. Yu, · C.-C. Shih, ·K.-J. Liu, · K.-L. Ou, · L.-Z. Hong, ·J. D. C. Chen, · C.-L. Chu.  A novel adjuvant Ling Zhi-8 enhances the efficacy of DNA cancer vaccine by activating dendritic cells.  Cancer Immunology and Immunotherapy, 60(7):1019-1027, 2011. (SCI 2014, IF=3.941, Journal ranking: Immunology:41/148=27.7%)
  26. H.-H. Chen, W. Chiang, J.-Y. Chang, Y.-L. Chien, C.-K. Lee, K.-J. Liu, Y.-T. Cheng, T.-F. Chen, Y.-H. Kuo, C.-C. Kuo. Antimutagenic Constituents of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) with Potential Cancer Chemopreventive Activity. Journal of Agricultural and Food Chemistry, 59:6444-6452, 2011 (SCI 2014 IF=2.912, Journal ranking: Agriculture, Multidisciplinary:2/56=3.6%)
  27. K.-J. Liu, S.-J. Leu, C.-H. Su, B.-L. Chiang, Y.-L. Chen, and Y.-L. Lee.  Administration of polysaccharides from Antrodia camphorata modulates dendritic cell function and alleviates allergen-induced Th2 responses in a mouse model of asthma.  Immunology, 129(3):351-362, 2010. (2014 IF=3.795, Journal raking: Immunology: 45/148=30.4%)
  28. J. Lung, K.-J. Liu, J.-Y. Chang, S.-J. Leu, and N.-Y Shih.  MBP-1 is efficiently encoded by an alternative transcript of the ENO1 gene but post-translationally regulated by proteasome-dependent protein turnover.  FEBS Journal. 277(20):4308-4321. 2010. (SCI 2014, IF=4.001, Journal ranking: Biochemistry & Molecular Biology, Multidisciplinary:77/290=26.6%)
  29. N.-Y. Shih, H.-L. Lai, G.-C. Chang, H.-C. Lin, Y.-C. Wu, J. M. Liu, K.-J. Liu and S.-W. Tseng.  Anti-α-enolase autoantibodies are down-regulated in advanced cancer patients.  Japanese Journal of Clinical Oncology.  40(7):663-669. 2010. (SCI 2014, IF=2.016, Journal ranking: Oncology:151/211=71.6%)
  30. S.-J. Leu, Y.-C. Lee, N.-Y. Shih, I-J. Huang, K.-J. Liu, H.-F. Lu, S.-Y. Huang and Y.-Y. Yang. Generation and characterization of anti-α-enolase single-chain antibodies in chicken. Veterinary Immunology and Immunopathology. 137:251-260. 2010. (SCI 2014, IF=1.535, Journal ranking: Veterinary Sciences:29/133=21.8%)
  31. J.-C. Chen, B.-J. Uang, P.-C. Lyu, J.-Y. Chang, K.-J. Liu, C.-C. Kuo, H.-P. Hsieh, H.-C. Wang, C.-S. Cheng, M.D.-T. Chang, W.-S.W. Chang, C.-C. Lin, Design and synthesis of α-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis. Journal of Medicinal Chemistry, 53(11):4545-9, 2010. (SCI 2014, IF=5.447, Journal ranking: Chemistry, Medicinal:3/59=5.1%)
  32. N.-Y. Shih, H.-Y. Yang, H.-T. Cheng, Y.-M. Hung, Y.-C. Yao, Y.-H. Zhu, Y.-C. Wu and K.-J. Liu (corresponding author).  Conditioning vaccination site with irradiated MIP-3 alpha-transfected tumor cells enhances efficacy of dendritic cell-based cancer vaccine against tumor challenge.  Journal of Immunotherapy, 32(4):363, 2009.  (SCI 2014 IF:4.008, Journal ranking: Immunology: 40/148=27.0%)
  33. B. L. Yen, C.-J. Chang, K.-J. Liu, Y.-C. Chen, H.-I Hu and M.-L. Yen.  Human embryonic stem cell-derived mesenchymal progenitors (EMPs) possess strong immunosuppressive effects towards natural killer cells as well as T lymphocytes.  Stem Cells, 27(2):451, 2009. (SCI 2014, IF=6.523, Journal ranking: Cell & Tissue engineerning:2/21=9.5%)
  34. Y.-M. Shiao, Y.-H. Chang, Y.-M. Liu, J.-C. Li, J.-S. Su, K.-J. Liu, Y.-F. Liu, M.-W. Lin and S.-F. Tsai.  Dysregulation of GIMAP genes in non-small cell lung cancer.  Lung Cancer, 62(3):287, 2008. (SCI 2014, IF=3.958, Journal ranking: Oncology 59/211=28%)
  35. K.-J. Liu and N.-Y. Shih.  The role of enolase in tissue invasion and metastasis of pathogens and tumor cells.  Journal of Cancer Molecules, 3(2):45, 2007.
  36. K.-J. Liu.  Dendritic cell, toll-like receptor, and the immune system.  Journal of Cancer Molecules, 2(6):213, 2006.
  37. G.-C. Chang, K.-J. Liu, C.-L. Hsieh, T.-S. Hu, S. Charoenfuprasert, H.-K. Liu, K.-T. Luh, L.-H. Hsu, C.-W. Wu, C.-C. Ting, C.-Y. Chen, K.-C. Chen, T.-Y. Yang, T.-Y. Chou, W.-H. Wang, J. Whang-Peng and N.-Y. Shih.  Identification of alpha-enolase as an autoantigen in lung cancer: its overexpression is associated with clinical outcomes.  Clinical Cancer Research, 12(19):5747, 2006. (SCI 2014, IF:8.722, Journal ranking: Oncology 12/211=5.7%)
  38. K.-J. Liu and C.-L. Chu.  Current progress in dendritic cell research.  Journal of Cancer Molecules, 2(6): 217, 2006.
  39. C.-C. Lee, K.-J. Liu, L.-L. Chen, Y.-C. Wu and T.-S. Huang.  Tumor necrosis factor-α, interleukin-8 and interleukin-6 are involved in vascular endothelial cell capillary tube and network formation induced by tumor-associated macrophages.  Journal of Cancer Molecules, 2(4): 155, 2006.
  40. C.-C. Lee, K.-J. Liu and T.-S. Huang.  Tumor-associated macrophage: its role in tumor angiogenesis.  Journal of Cancer Molecules, 2(4): 135, 2006.
  41. G.-C. Chang, H.-C. Lan, S.-H. Juang, Y.-C. Wu, H.-C. Lee, Y.-M. Hung, J. Whang-Peng and K.-J. Liu (corresponding author).  A Pilot Clinical Trial of Vaccination with Dendritic Cells Pulsed with Autologous Tumor Cells Derived from Malignant Pleural Effusion in Patients with Late-stage Lung Cancer.  Cancer, 103(4):763, 2005. (SCI 2009, IF: 5.418)
  42. C.-C. Chen, J.-Y. Chang, K.-J. Liu, C. Chan, C.-H. Ho, S.-C. Lee and L.-T. Chen.  Hepatocellular carcinoma associated with acquired von Willebrand disease and extreme thrombocytosis.  Annals of Oncology, 16(6):988, 2005. (SCI 2009, IF:5.647)
  43. K.-J. Liu, C.-C. Wang, L.-T. Chen, A.-L. Cheng, D.-T. Lin, Y.-C. Wu, W.-L. Yu, Y.-M. Hung, H.-Y. Yang, S.-H. Juang and J. Whang-Peng.  Generation of CEA-specific T cell responses in HLA-A*0201 and HLA-A*2402 late-stage colorectal cancer patients after vaccination with dendritic cells loaded with CEA peptides.  Clinical Cancer Research, 10(8):2645, 2004. (SCI 2009, IF: 6.747)
  44. K.-J. Liu (corresponding author), L.-F. Lu, H.-T. Cheng, Y.-M. Hung, S.-R. Shiou, J. Whang-Peng and S.-H. Juang.  Concurrent delivery of tumor antigens and activation signals to dendritic cells by irradiated CD40 ligand-transfected tumor cells resulted in efficient activation of specific CD8+ T cells.  Cancer Gene Therapy, 11:135, 2004. (SCI 2009, IF: 3.126)
  45. K.-J. Liu, C.-T. Chen, W. S. Hu, Y.-M. Hung, C.-Y. Hsu, B.-F. Chuang and S.-H. Juang.  Expression of cytoplasmic-domain substituted epeidermal growth factor receptor inhibits tumorigenicity of EGFR-overexpressed human glioblastoma multiforme.  International Journal of Oncology, 24(3):581, 2004. (SCI 2009, IF: 2.447)
  46. S.-H. Juang, S.-J. Wei, C.-Y. Hsu, Y.-M. Hung, K.-J. Liu, D.-M. Yang, W.-S. Chen and W. K. Yang.  Interferon-b induces Caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines.  Journal of Interferon and Cytokine Research, 24(4):231, 2004. (SCI 2009, IF: 1.627)

Book:

  1. Yen BL, Yen ML, Liu KJ, Chiu RC.  Recent Advances in Stem Cell Immune Tolerance, In: Emile B. Pontell, ed. Immune Tolerance Research Developments. Hauppauge, NY: Nova Science Publishers, Chapter 7, pp. 151-166, 2008.
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