李岳倫 副研究員-論文

SELECTED PUBLICATION:

A. Referred papers:
  1. E Liu#, Alan Yueh-Luen Lee#, T Chiba, E Olsen, P Sun and X Wu (2007) The ATR-mediated S-phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted. Journal of Cell Biology 179 (4): 643-657. (#: These authors contribute equally to this work)
  2. HM Wang, KC Cheng, CJ Lin, SW Hsu, WC Fang, TF Hsu, CC Chiu, HW Chang, CH Hsu and Alan Yueh-Luen Lee.* (2010) Obtusilactone A and (-)-sesamin induce apoptosis in human lung cancer cells via inhibiting mitochondrial Lon protease and activating DNA damage checkpoints. Cancer Science 101(12): 2612-2620. (*corresponding author)
  3. Alan Yueh-Luen Lee,* T Chiba, LN Truong, AN Cheng, J Do, MJ Cho, L Chen, and X Wu * (2012) Dbf4 is direct downstream target of Ataxia Telangiectasia Mutated (ATM) and Ataxia Telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint. Journal of Biological Chemistry 287(4): 2531–2543.( *corresponding author)
  4. HC Wang*, Alan Yueh-Luen Lee, WC Chou, CC Wu, CN Tseng, KYT Liu, WL Lin, FR Chang, DW Chuang, A Hunyadi, and YC Wu* (2012) Inhibition of ATR-dependent signaling by protoapigenone and its derivative sensitize cancer cells to interstrand cross-link-generating agents in vitro and in vivo. Molecular Cancer Therapeutics 11(7): 1443-1453.
  5. AN Cheng#, SS Jiang#, CC Fan#, YK Lo, CY Kuo, CHs Chen, YL Liu, CC Lee, WS Chen, TS Huang, TY Wang and Alan Yueh-Luen Lee.* (2013) Increased Cdc7 expression is a marker of oral squamous cell carcinoma and overexpression of Cdc7 contributes to the resistance to DNA-damaging agents. Cancer Letters 337(2): 218-225 (*corresponding author)
  6. CW Cheng#, CY Kuo#, CC Fan#, WC Fang, SS Jiang, YK Lo, TY Wang, MC Kao, and Alan Yueh-Luen Lee*. (2013) Overexpression of Lon contributes to survival and aggressive phenotype of cancer cells through mitochondrial complex I-mediated generation of reactive oxygen species. Cell Death and Disease 4: e681 (*corresponding author)
  7. CC Fan, TY Wang, YA Cheng, SS Jiang, CW Cheng, Alan Yueh-Luen Lee*, TY Kao*. (2013) Expression of E-cadherin, Twist, and p53 and their prognostic value in patients with oral squamous cell carcinoma. Journal of Cancer Research and Clinical Oncology 139(10): 1735–1744 (*corresponding author)
  8. WT Fang, CC Fan, SP Lin, SM Li, NY Shih, CH Chen, TY Wang, SF Huang, Alan Yueh-Luen Lee, YL Liu, FY Tsai, CT Huang, TH Jang, SJ Yang, LJ Yen, CY Chen, CA Hsiung, JY Chang, LH Wang, IS Chang, and SS Jiang. (2014) Downregulation of a putative tumor suppressor BMP4 by SOX2 promotes growth of lung squamous cell carcinoma. International Journal of Cancer 135(4): 809-19
  9. CH Chen, DS Lin, CW Cheng, CJ Lin, YK Lo, CC Yen, Alan Yueh-Luen Lee* and CD Hsiao*.  (2014) Cdc6 cooperates with c-Myc to promote genome instability and epithelial to mesenchymal transition EMT in zebrafish. Oncotarget 5(15): 6300-11 (*corresponding author). 媒體報導:癌症轉移斑馬魚,助找到抑制藥物。http://www.uho.com.tw/hotnews.asp?aid=36263
  10. TY Kao , YC Chiu, WC Fang, CW Cheng, CY Kuo, HF Juan, SH Wu*, and Alan Yueh-Luen Lee*. (2015) Mitochondrial Lon regulates apoptosis through the association with Hsp60-mtHsp70 complex. Cell Death and Disease 6, e1642 (*corresponding author)
  11. Chan-Yen Kuo, Yi-Chieh Chiu, Alan Yueh-Luen Lee*, Tsong-Long Hwang* (2015) Mitochondrial Lon protease controls ROS-dependent apoptosis in cardiomyocyte under hypoxia. Mitochondrion 23: 7-16. (*corresponding author)
  12. Alan Yueh-Luen Lee, CC Fan, YA Chen, CW Cheng, YJ Sung, CP Hsu, TY Kao*. (2015) Curcumin inhibits invasiveness and epithelial-mesenchymal transition in oral squamous cell carcinoma through reducing matrix metalloproteinase 2, 9 and modulating p53-E-cadherin pathway. Integrative Cancer Therapies 14(5): 484-490.
  13. DS Lin, CD Hsiao, Alan Yueh-Luen Lee, CS Ho, HL Liu, TJ Wang, YR Jian, JC Hsu, ZD Huang, TH Lee, MF Chiang. (2015) Mitigation of cerebellar neuropathy in globoid cell leukodystrophy mice by AAV-mediated gene therapy. Gene 571(1):81-90.
  14. Jui-Ling Tsai, Yu-May Lee, Chien-Yuan Pan, Alan Yueh-Luen Lee* (2016) The novel VEGF121-VEGF165 fusion attenuates angiogenesis and drug resistance via targeting VEGFR2-HIF-1α-VEGF165/Lon signaling through PI3K-AKT-mTOR pathway. Current Cancer Drug Targets 16(3):275-86 (*corresponding author)
  15. CW Cheng#, JR Hsiao#, CC Fan#, YK Lo, CY Tzen, LW Wu, WY Fang, AJ Cheng, CH Chen, SS Jiang , IS Chang, JY Chang, and Alan Yueh-Luen Lee*. (2016) Loss of GDF10/BMP3b as a prognostic marker collaborates with TGFBR3 to enhance chemotherapy resistance and epithelial-mesenchymal transition in oral squamous cell carcinoma. Molecular Carcinogenesis 55(5):499-513 (*corresponding author)
  16. J Shao, S Zhou, Z Jiang, T Chi, J Ma, M Kuo, Alan Yueh-Luen Lee and L Jia (2016) Warfarin and coumarin-like Murraya paniculata extract down-regulate EpCAM-mediated cell adhesion: individual components versus mixture for studying botanical metastatic chemopreventives. Scientific Reports 6: 30549.
  17. AN Cheng#, CC Fan#, YK Lo, CL Kuo, HC Wang, SY Lin, CH Chen, SS Jiang, IS Chang, HF Juan, PC Lyu, and Alan Yueh-Luen Lee*. (2017) Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer. Scientific Reports 7: 17024 (*corresponding author)
  18. YJ Sung#, TY Kao#, CL Kuo# , CC Fan, AN Cheng, WC Fang, HY Chou, YK Lo, CH Chen, SSJiang, IS Chang, CH Hsu, JC Lee, and Alan Yueh-Luen Lee*. (2018) Mitochondrial Lon sequesters and stabilizes p53 in the matrix to restrain apoptosis under oxidative stress via its chaperone activity. Cell Death and Disease 9: 697 (*corresponding author)
  19. C-H Lu, D-W Yeh, C-Y Lai, Y-L Liu, L-R Huang, Alan Yueh-Luen Lee, S.-L. C. Jin & T-H Chuang. (2018) USP17 mediates macrophage-promoted inflammation and stemness in lung cancer cells by regulating TRAF2/TRAF3 complex formation. Oncogene (In press)
  20. L-C Cheng, Y-L Chen, A-N Cheng, Alan Yueh-Luen Lee, C-Y Cho, J-S Huang, S-E Chuang. (2018) AXL phosphorylates and up-regulates TNS2 and its implication in IRS1-associated metabolism in cancer cells. Journal of Biomedical Science (In press)
  21. An Ning Cheng#, Yu-Kang Lo#, Yi-Sheng Lin, Tswen-Kei Tang, Chun-Hua Hsu, John T.-A. Hsu, and Alan Yueh-Luen Lee*. (2018) Identification of novel Cdc7 kinase inhibitors as anti-cancer agents that target the interaction with Dbf4 by the fragment complementation and drug repositioning approach. EBioMedicine 36: 241-251 (*corresponding author) 雜誌專文評論介紹: A new screening method for ATP-independent kinase inhibitors identifies repurposed anti-cancer drugs. https://www.ebiomedicine.com/article/S2352-3964(18)30431-6/fulltext
B. Proceeding of Meeting (Invited speaker):
  1. Alan Yueh-Luen Lee, Chien-Wen Cheng, and Chan-Yen Kuo. Overexpression of mitochondrial Lon protease contributes malignant tumor progression. (Symposia/S8-5). The 71st annual meeting of The Japanese Cancer Association. Sapporo, Japan, September 19-21, 2012.
  2. CH Chen, CJ Lin, YK Lo, and CD Hsiao, Alan Yueh-Luen Lee. (Section VIII) Cdc6 cooperates with c-Myc in oncogenic transformation in zebrafish skin. 第二屆海峽兩岸斑馬魚學術研討會,中國青島,July 16-19, 2013
  3. Alan Yueh-Luen Lee. Cdc6 cooperates with c-Myc to promote tumorigenesis and EMT in a skin model of zebrafish. (E-2003). The 73rd annual meeting of The Japanese Cancer Association. Yokohama, Japan, September 25-27, 2014.
  4. Alan Yueh-Luen Lee. Role of Mitochondrial Lon in Promoting Epithelial-Mesenchymal Transition and Angiogenesis under Hypoxic Tumor Microenvironment. The 67th Annual Meeting of the Japan Society for Cell Biology. Tokyo, Japan, June 30- July 2, 2015.
  5. Alan Yueh-Luen Lee. (Session 02-2) 2015 Taiwan Society for Mitochondrial Research and Medicine annual meeting & symposium on mitochondrial dysfunction in human diseases. Taipei, Taiwan, December 5, 2015.
  6. Invited as Taiwan Academic Panelist. The 2016 Boston Taiwanese of Biotechnology Association (BTBA) symposium. Boston, USA, July 16-17, 2016.
  7. Alan Yueh-Luen Lee. Mitochondrial Lon Promotes Epithelial-Mesenchymal Transition and Angiogenesis under Hypoxia via ROS-mediated Signaling. (Session C1-1). 4th International Symposium of Australasian College of Medical Sciences and Research & 2016 Annual Meeting of Taiwan Society for Mitochondrial Research and Medicine. Changhua, Taiwan, September 24-25, 2016
  8. Alan Yueh-Luen Lee. Cdc7-Dbf4 overrides replication stress to promote cancer cell survival by targeting ATR-HSP90-HCLK2 signaling through phosphorylation of HSP90. (E-3030). The 75th annual meeting of The Japanese Cancer Association. Yokohama, Japan, October 8-10, 2016.
  9. Alan Yueh-Luen Lee. Mitochondrial Stress Promotes Cancer Metastasis via ROS-p38/NF-κB Inflammation Pathways. (Session 1). International Conference on Recent Advances in Inflammation 2016. Tainan, Taiwan, November 11-12, 2016
  10. Alan Yueh-Luen Lee. Mitochondrial Lon-mediated survival responses to oxidative stress in tumor microenvironment. (Talk 6). 2017 Mini Symposium on Mitochondrial Structure and Function, Lecture Hall, ICOB, Academia Sinica, Taipei Taiwan, October 23, 2017
  11. Alan Yueh-Luen Lee. The survival response to mitochondrial stress in tumor microenvironment: From mechanism to cancer therapy. (Session S03-3). 2017 Annual Meeting of Taiwan Society for Mitochondrial Research and Medicine. Kaohsiung, Taiwan, November 4, 2017
  12. Alan Yueh-Luen Lee. The survival response to mitochondrial oxidative stress endues tumorigeneity in tumor microenvironment. (Mitochondrial Medicine Section). The 33rd Joint Annual Conference of Biomedical Science-The Taiwan Society for Biochemistry and Molecular Biology. Taipei, Taiwan, March 24, 2018
  13. Alan Yueh-Luen Lee. The survival response to mitochondrial oxidative stress endues tumorigeneity in tumor microenvironment. Department of Biochemistry, Tzu Chi University. Hualien, Taiwan, April 30, 2018
  14. Alan Yueh-Luen Lee. The survival response to mitochondrial oxidative stress endues tumorigeneity in tumor microenvironment. Department of Life Sciences, National Central University, Chongli,  Taiwan, May 22, 2018
  15. Alan Yueh-Luen Lee. The survival response to mitochondrial stress endues tumorigeneity via affecting tumor microenvironment. School of Life Sciences, Special Lectures on Biomedicine (生命科學院生醫特別講座), National Yang-Ming University, Taipei, Taiwan, September 19, 2018
C. Articles:
  1. 李岳倫,「揭開黑死病的神秘面紗」,科學月刊,民國90年,第32期第3卷:  p248-p249
  2.  李岳倫,「別成為失根的蘭花–論­人才培育與台灣科學及生物科技發展」,科技報導,2016 年2月號,410: p4-5
  3. 李岳倫,「發現沒有粒線體的真核生物?」,科學月刊,559,2016/7,第47期第7卷:p494
  4. 李岳倫,「談美國癌症登月計畫以及對臺灣的啟示」,科學月刊,560,2016/8,第47期第8卷: p622-p625
  5. 李岳倫,「諾貝爾生醫獎─大隅良典與細胞自噬」,科學月刊,564,2016/12,第47期第12卷: p912-p917
  6. 李岳倫,「粒線體遺傳疾病、置換治療與三親嬰兒」,科學月刊,568,2017/4,第48期第4卷: p266-p269
  7. 李岳倫,「治癌變控癌,讓它變成慢性病」,聯合報科普好健康版, 2018.9.22. https://udn.com/news/story/7266/3381078
  8. 李岳倫,「顛覆癌症治療的革命—免疫治療的前世、今生與未來」,科學月刊,587,2018/11: p816-p817
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