洪文俊 研究員-論文

PUBLICATIONS

(2013-current): *corresponding author

  1. Cheng HT, Hung WC*. (2013) Inhibition of lymphangiogenic factor VEGF-C expression and production by the histone deacetylase inhibitor suberoylanilide hydroxamic acid in breast cancer cells. Oncology Reports 29:1238-1244.
  2. Chang TM, Hung WC*. (2013) The homeobox transcription factor Prox1 inhibits proliferation of hepatocellular carcinoma cells by inducing p53-dependent senescence-like phenotype. Cancer Biology & Therapy 14:222-229.
  3. Chiang CH, Hou MF, Hung WC*. (2013) Up-regulation of miR-182 by β-catenin in breast cancer increases tumorigenicity and invasiveness by targeting the matrix metalloproteinase inhibitor RECK. Biochim Biophys Acta 1830:3067-3076.
  4. Yang ST, Yen CJ, Lai CH, Lin YJ, Chang KC, Lee JC, Liu YW, Chang-Liao PY, Hsu LS, Chang WC, Hung WC, Tang TK, Liu YW, Hung LY. (2013) SUMOylated CPAP is required for IKK-mediated NF-κB activation and enhances HBx-induced NF-κB signaling in HCC. Journal of Hepatology 58: 1157-1164.
  5. Huang YC, Hung WC, Chen WT, Yu HS, Chai CY. (2013) Expression of WWOX and FHIT is downregulated by exposure to arsenite in human uroepithelial cells. Toxicology Letter 220:118-125.
  6. Cheng HT, Hung WC*. (2013) Inhibition of proliferation, sprouting, tube formation and Tie2 signaling of lymphatic endothelial cells by the histone deacetylase inhibitor SAHA. Oncology Reports 30: 961-967.
  7. Lin HY, Chiang CH, Hung WC*. (2013) STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells. British Journal of Cancer 109:731-738.
  8. Huang HL, Hsu HP, Shieh SC, Chang YS, Chen WC, Cho CY, Teng CF, Su IJ, Hung WC, Lai MD. (2013) Attenuation of argininosuccinate lyase inhibits cancer growth via cyclin A2 and nitric oxide. Molecular Cancer Therapeutics 12:2505-2516.
  9. Hong KJ, Wu DC, Cheng KH, Chen LT, Hung WC*. (2014) RECK inhibits stemness gene expression and tumorigenicity of gastric cancer cells by suppressing ADAM-mediated Notch1 activation. Journal of Cellular Physiology 229:191-201.
  10. Yen YC, Shiah SG, Chu HC, Hsu YM, Hsiao JR, Chang JY, Hung WC, Liao CT, Cheng AJ, Lu YC, Chen YW. (2014) Reciprocal regulation of microRNA-99a and insulin-like growth factor I receptor signaling in oral squamous cell carcinoma cells. Molecular Cancer 13:6.
  11. Jian SF, Hsiao CC, Chen SY, Weng CC, Kuo TL, Wu DC, Hung WC, Cheng KH. (2014) Utilization of liquid chromatography mass spectrometry analyses to identify LKB1-APC interaction in modulating Wnt/β-catenin pathway of lung cancer cells. Molecular Cancer Research 12:622-635.
  12. Chen YW, Hsiao PJ, Weng CC, Kuo KK, Kuo TL, Wu DC, Hung WC, Cheng KH. (2014) SMAD4 loss triggers the phenotypic changes of pancreatic ductal adenocarcinoma cells. BMC Cancer 14:181.
  13. Su ML, Chang TM, Chiang CH, Chang HC, Hou MF, Li WS*, Hung WC*. (2014) Inhibition of chemokine (C-C motif) receptor 7 sialylation suppresses CCL19-stimulated proliferation, invasion and anti-anoikis. PLoS One 9:e98823.
  14. Wang CH, Chen CL, More SV, Hsiao PW, Hung WC*, Li WS*. (2014) The tetraindole SK228 reverses the epithelial-to-mesenchymal transition of breast cancer cells by up-regulating members of the miR-200 family. PLoS One 9:e101088.
  15. Chang YW, Su CM, Su YH, Ho YS, Lai HH, Chen HA, Kuo ML, Hung WC, Chen YW, Wu CH, Chen PS, Su JL. (2014) Novel peptides suppress VEGFR-3 activity and antagonize VEGFR-3-mediated oncogenic effects. Oncotarget 5:3823-3835.
  16. Chen JY, Li CF, Kuo CC, Tsai KK, Hou MF, Hung WC*. (2014) Cancer/stroma interplay via cyclooxygenase-2 and indoleamine 2,3-dioxygenase promotes breast cancer progression. Breast Cancer Research 16:410.
  17. Huang HL, Chiang CH, Hung WC*, Hou MF*. (2015) Targeting of TGF-β-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer. Oncotarget 6:995-1007.
  18. Yeh HH, Tseng YF, Hsu YC, Lan SH, Wu SY, Raghavaraju G, Cheng DE, Lee YR, Chang TY, Chow NH, Hung WC, Liu HS. (2015) Ras induces experimental lung metastasis through up-regulation of RbAp46 to suppress RECK promoter activity. BMC Cancer 15:172.
  19. Lai YS, Chen JY, Tsai HJ, Chen TY, Hung WC*. (2015) The SUV39H1 inhibitor chaetocin induces differentiation and shows synergistic cytotoxicity with other epigenetic drugs in acute myeloid leukemia cells. Blood Cancer Journal 5:e313.
  20. Chen HM,Tsai CH, Hung WC*. (2015) Foretinib inhibits angiogenesis, lymphangiogenesis and tumor growth of pancreatic cancer in vivo by decreasing VEGFR-2/3 and TIE-2 signaling. Oncotarget 6:14940-14952.
  21. Hong KJ, Hsu MC, Hung WC*. (2015) RECK impedes DNA repair by inhibiting the erbB/JAB1/Rad51 signaling axis and enhances chemosensitivity of breast cancer cells. American Journal of Cancer Research 5:2422-2430.
  22. Chiang NJ, Shan YS, Hung WC, Chen LT. (2015) Epigenetic regulation in the carcinogenesis of cholangiocarcinoma. International Journal of Biochemistry and Cell Biology 67:110-114.
  23. Pan MR, Hsu MC, Chen LT, Hung WC*. (2015) G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation. Scientific Reports 5:18709.
  24. Kuo TL, Weng CC, Kuo KK, Chen CY, Wu DC, Hung WC, Cheng KH. (2016) APC haploinsufficiency coupled with p53 loss sufficiently induces mucinous cystic neoplasms and invasive pancreatic carcinoma in mice. Oncogene 35:2223-2234.
  25. Weng CC, Kuo KK, Su HT, Hsiao PJ, Chen YW, Wu DC, Hung WC, Cheng KH. (2016) Pancreatic tumor progression associated with CD133 overexpression: Involvement of increased TERT expression and epidermal growth factor receptor-dependent Akt activation. Pancreas 45:443-457.
  26. Chen JY, Li CF, Chu PY, Lai YS, Chen CH, Jiang SS, Hou MF, Hung WC*. (2016) Lysine demethylase 2A promotes stemness and angiogenesis of breast cancer by upregulating Jagged1. Oncotarget 7:27689-27710.
  27. Hsu MC, Hung WC, Yamaguchi H, Lim SO, Liao HW, Tsai CH, Hung MC. (2016) Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathway. American Journal of Cancer Research 6:628-638.
  28. Pan MR, Li K, Lin SY, Hung WC*. (2016). Connecting the Dots: From DNA Damage and Repair to Aging. International Journal of Molecular Science 17: E685. (Invited review).
  29. Pan MR, Hsu MC, Luo CW, Chen LT, Shan YS, Hung WC*. (2016) The histone methyltransferase G9a as a therapeutic target to override gemcitabine resistance in pancreatic cancer. Oncotarget. 7(38):61136-61151.
  30. Chen JY, Lai YS, Tsai HJ, Kuo CC, Yen BL, Yeh SP, Sun HS, Hung WC*. (2016) The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor- promoting stromal niche for acute myeloid leukemia cells. Scientific Reports 6:32428.
  31.  Yin HL, Wu CC, Lin CH, Chai CY, Hou MF, Chang SJ, Tsai HP, Hung WC, Pan MR, Luo CW. (2016) β1 Integrin as a Prognostic and Predictive Marker in Triple-Negative Breast Cancer. International Journal of Molecular Science 17: E1432.
  32. Chiang CH, Chu PY, Hou MF, Hung WC*. (2016) MiR-182 promotes proliferation and invasion and elevates the HIF-1α-VEGF-A axis in breast cancer cells by targeting FBXW7. American Journal of Cancer Research 6:1785-98.
  33. Chen JY, Luo CW, Lai YS, Wu CC, Hung WC*. (2017) Lysine demethylase KDM2A inhibits TET2 to promote DNA methylation and silencing of tumor suppressor genes in breast cancer. 2 Oncogenesis 6(8):e369.
  34. Luo CW, Wang JY, Hung WC, Peng G, Tsai YL, Chang TM, Chai CY, Lin CH, Pan MR. (2017) G9a governs colon cancer stem cell phenotype and chemoradioresistance through PP2A-RPA axis-mediated DNA damage response. Radiotherapy & Oncology 124:395-402.
  35. Cho YT, Su H, Chiang YY, Shiea J, Yuan SF, Hung WC, Yeh YT, Hou MF. (2017) Fine Needle Aspiration Combined With Matrix-assisted Laser Desorption Ionization Time-of-Flight/Mass Spectrometry to Characterize Lipid Biomarkers for Diagnosing Accuracy of Breast Cancer. Clinical Breast Cancer 17:373-381.
  36. Weng CC, Hawse JR, Subramaniam M, Chang VHS, Yu WCY, Hung WC, Chen LT, Cheng KH. (2017) KLF10 loss in the pancreas provokes activation of SDF-1 and induces distant metastases of pancreatic ductal adenocarcinoma in the KrasG12D p53flox/flox model. Oncogene 36:5532-5543.
  37. Hou MF, Luo CW, Chang TM, Hung WC, Chen TY, Tsai YL, Chai CY, Pan MR. (2017) The NuRD complex-mediated p21 suppression facilitates chemoresistance in BRCA-proficient breast cancer. Experimental Cell Research 359:458-465.
  38. Pan MR, Hsu MC, Chen LT, Hung WC*. (2018) Orchestration of H3K27 methylation: mechanisms and therapeutic implication. Cellular Molecular Life Science 75:209-223.
  39. Hsu MC, Hung WC*. (2018) Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling. Molecular Cancer 17:35.
  40. Tian YF, Wang HC, Luo CW, Hung WC, Lin YH, Chen TY, Li CF, Lin CY, Pan MR. (2018) Preprogramming therapeutic response of PI3K/mTOR dual inhibitor via the regulation of EHMT2 and p27 in pancreatic cancer. American Journal of Cancer Research 8:1812-1822.
  41. Luo CW, Hsiao IL, Wang JY, Wu CC, Hung WC, Lin YH, Chen TY, Hsu YC, Cheng TL, Pan MR. (2018) Cell Motility Facilitated by Mono(2-ethylhexyl) Phthalate via Activation of the AKT-β-Catenin-IL-8 Axis in Colorectal Cancer. Journal of Agricultural & Food Chemistry 66:9635-9644.
  42. Weng CC, Ding PY, Liu YH, Hawse JR, Subramaniam M, Wu CC, Lin YC, Chen CY, Hung WC, Cheng KH. Mutant Kras-induced upregulation of CD24 enhances prostate cancer stemness and bone metastasis. Oncogene (accepted).
  43. Chan SH, Tsai KW, Chiu SY, Kuo WH, Chen HY, Jiang SS, Chang KJ, Hung WC and Wang LH. (2018) Identification of the novel role of CD24 as an oncogenesis regulator and therapeutic target for Triple Negative Breast Cancer. Molecular Cancer Therapeutics (accepted).
  44. Kuo TL, Cheng KH, Shan YS, Chen LT and Hung WC* (2018)β-catenin-activated autocrine PDGF/Src signaling is a therapeutic target in pancreatic cancer. Theranostics (under revision).
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