陳雅雯 副研究員-論文

PUBLICATIONS

[ Peer-reviewed Articles ] (* corresponding author)

  1. Yeh, S.H., Chen, P.J., Shau, W.Y., Chen, Y.W. , Lee, P.H., Chen, J.T. and Chen, D.S. (2001) Chromosomal allelic imbalance evolving from liver cirrhosis to hepatocellular carcinoma. Gastroenterology, 121, 699-709.
  2. Yeh, S.H., Chang, C.F., Shau, W.Y., Chen, Y.W., Hsu, H.C., Lee, P.H., Chen, D.S. and Chen, P.J. (2002) Dominance of functional androgen receptor allele with longer CAG repeat in hepatitis B virus-related female hepatocarcinogenesis. Cancer Res, 62, 4346-51.
  3. Chen, Y.W., Jeng, Y.M., Yeh, S.H. and Chen, P.J. (2002) P53 gene and Wnt signaling in benign neoplasms: beta-catenin mutations in hepatic adenoma but not in focal nodular hyperplasia. Hepatology, 36, 927-35.
  4. Chen, Y.W., Klimstra, D.S., Mongeau, M.E., Tatem, J.L., Boyartchuk, V. and Lewis, B.C. (2007) Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells. Cancer Res, 67, 7589-96.
  5. Paliwal, S., Kovi, R.C., Nath, B., Chen, Y.W., Lewis, B.C. and Grossman, S.R. (2007) The alternative reading frame tumor suppressor antagonizes hypoxia-induced cancer cell migration via interaction with the COOH-terminal binding protein corepressor. Cancer Res, 67, 9322-9.
  6. Chen, Y.W., Paliwal, S., Draheim, K., Grossman, S.R. and Lewis, B.C. (2008) p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein. Cancer Res, 68, 476-82.
  7. Chen, Y.W., Boyartchuk, V. and Lewis, B.C. (2009) Differential roles of insulin-like growth factor receptor- and insulin receptor-mediated signaling in the phenotypes of hepatocellular carcinoma cells. Neoplasia, 11, 835-45.
  8. Lin, Z.S., Chu, H.C., Yen, Y.C., Lewis, B.C. and Chen, Y.W.* (2012) Kruppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression. PLoS One, 7, e43593.
  9. Kuo, Y.Y., Lin, H.P., Huo, C., Su, L.C., Yang, J., Hsiao, P.H., Chiang, H.C., Chung, C.J., Wang, H.D., Chang, J.Y., Chen, Y.W. and Chuu, C.P. (2013) Caffeic Acid Phenethyl Ester Suppresses Proliferation and Survival of TW2.6 Human Oral Cancer Cells via Inhibition of Akt Signaling. Int J Mol Sci, 14, 8801-17.
  10. Lin, C.Y., Huo, C., Kuo, L.K., Hiipakka, R.A., Jones, R.B., Lin, H.P., Hung, Y., Su, L.C., Tseng, J.C., Kuo, Y.Y., Wang, Y.L., Fukui, Y., Kao, Y.H., Kokontis, J.M., Yeh, C.C., Chen, L., Yang, S.D., Fu, H.H., Chen, Y.W., Tsai, K.K., Chang, J.Y. and Chuu, C.P. (2013) Cholestane-3beta, 5alpha, 6beta-triol Suppresses Proliferation, Migration, and Invasion of Human Prostate Cancer Cells. PLoS One, 8, e65734.
  11. Chen, Y.W.*, Chu, H.C., Lin, Z.S., Shiah, W.J., Chou, C.P., Klimstra, D.S. and Lewis, B.C. (2013) p16 Stimulates CDC42-Dependent Migration of Hepatocellular Carcinoma Cells. PLoS One, 8, e69389.
  12. Jiao, B., Taniguchi-Ishigaki, N., Gungor, C., Peters, M.A., Chen, Y.W., Riethdorf, S., Drung, A., Ahronian, L.G., Shin, J., Pagnis, R., Pantel, K., Tachibana, T., Lewis, B.C., Johnsen, S.A. and Bach, I. (2013) Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleo-cytoplasmic shuttling. Mol Biol Cell. 24, 3085-96.
  13. Chen, Y.W., Pan, H.B., Tseng, H.H., Hung, Y.T., Huang, J.S. and Chou, C.P. (2013) Assessment of blood flow in hepatocellular carcinoma: correlations of computed tomography perfusion imaging and circulating angiogenic factors. Int J Mol Sci, 14, (9), 17536-52.
  14. Chen, Y.W., Pan, H.B., Tseng, H.H., Chu, H.C., Hung, Y.T., Yen, Y.C. and Chou, C.P. (2013) Differentiated epithelial- and mesenchymal-like phenotypes in subcutaneous mouse xenografts using diffusion weighted-magnetic resonance imaging. Int J Mol Sc, 14, (11), 21943-59.
  15. Yen YC, Shiah SG., Chu HC., Hsu YM., Hsiao J.R., Chang J.Y., Hung W.C., Liao C. T., Lu Y. C. and Chen Y.W.* (2014) Reciprocal regulation of microRNA-99a and insulin-like growth factor I receptor signaling in oral squamous cell carcinoma cells. Mol Cancer 13 (1), 6.
  16. Chang, YW., Su, CM., Su, YH., Ho, YS., Lai, HH., Chen, H.A., Kuo, M.L., Hung, W.C., Chen, Y.W., Wu, C.H., Chen, P.S., and Su, J.L. (2014) Novel peptides suppress VEGFR-3 activity and antagonize VEGFR-3-mediated oncogenic effects. Oncotarget, 5, (11), 3823-35.
  17. Shiah, S.G., Hsiao, J.R., Chang, W.M., Chen, Y.W., Jin, Y.T., Wong, T.Y., Huang, J.S., Tsai, S.T., Hsu, Y.M., Chou, S.T., Yen, Y.C., Jiang, S.S., Shieh, Y.S., Chang, I.S., Hsiao, M. and Chang, J.Y. (2014) Downregulated miR-329 and miR-410 promote the proliferation and invasion of oral squamous cell carcinoma by targeting Wnt-7b. Cancer Res. 74, (24), 1-13.
  18. Chen, Y.W., Tsai, M.Y., Pan, H.B., Tseng, H.H., Hung, Y.T. and Chou, C.P. (2014) Gadoxetic acid-enhanced MRI and sonoelastography: non-Invasive assessments of chemoprevention of liver fibrosis in thioacetamide-induced rats with Sho-Saiko-To. PLoS One, 9, e114756.
  19. Yeh, C.F., Tai, W., Lin, C.H., Juang, D., Wu, C.C., Chen, Y.W. and Hsu C.H. (2015) Towards an Endpoint Cell Motility Assay by a Microfluidic Platform. IEEE Trans Nanobioscience, 14, 835-40.
  20. Yen, Y.C., Hsiao, J. R., Jiang, S.S., Chang, J.S., Wang, S.H., Shen, Y.Y., Chen, C.H., Chang, I.S., Chang J.Y. and Chen, Y.W.* (2015) Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells by requirement of integrin β1. Oncotarget, 6, (39), 41837-55.
  21. Chen, Y.W., Liou, G.G., Pan, H. B., Tseng, H.H., Hung, Y.T., and Chou, C.P. (2015) Specific detection of CD133-positive tumor cells with iron oxide nanoparticles labeling using noninvasive molecular magnetic resonance imaging. International J of Nanomedicine, 10, 6997-7018.
  22. Ahronian, L.G., Zhu, L.J., Chen, Y.W., Chu, H.C., Klimstra, D.S., and Lewis, B.C. (2016) A novel KLF6-Rho GTPase axis regulates hepatocellular carcinoma cell migration and dissemination. Oncogene, 35(35):4653-62.
  23. Chou, C.P*., Jiang, S.S., Pan, H.B., Yen, Y.C., Tseng, H.H., Hung, Y.T., Wang, S.H., Chen, Y.L., Chen, Y.W.* (2016) Endothelial cell colony forming units derived from malignant breast diseases are resistant to tumor necrosis factor-α-induced apoptosis. Sci Rep., 6:37450.
  24. Yeh, D.W., Huang, L.R., Chen, Y.W., Huang, C.F., Chuang, T.H. (2016) Interplay between Inflammation and Stemness in Cancer Cells: The Role of Toll-Like Receptor Signaling. J Immunol Res, 2016:4368101.
  25. Wang, S.H., Chang, J. S., Hsiao, J.R., Yen, Y.C., Jiang, S.S., Liu, S.H., Chen, Y.L., Shen Y.Y., Chang, J.Y., and Chen, Y.W.* (2017) Tumor cell-derived WNT5B modulates in vitro lymphangiogenesis via induction of partial endothelial mesenchymal transition of lymphatic endothelial cells. Oncogene, 36(11):1503-1515.
  26. Li, S.M., Chen, C.H., Chen, Y.W., Yen, Y.C., Fang, W.T., Tsai, F.Y., Chang, J.L., Shen, Y.Y., Huang, S.F., Chuu, C.P., Chang I.S., Hsiung C.A., Jiang S.S. (2017) Upregulation of CISD2 augments ROS homeostasis and contributes to tumorigenesis and poor prognosis of lung adenocarcinoma. Sci Rep. 7(1):11893.
  27. Wang, S.H., Liou, G.G., Liu, S.H., Chang, J.S., Hsiao, J.R., Yen, Y.C., Chen, Y.L., Wu, W.L., Chang, J.Y., Chen, Y.W.* (2019) Laminin γ2-enriched extracellular vesicles of oral squamous cell carcinoma cells enhance in vitro lymphangiogenesis via integrin α3-dependent uptake by lymphatic endothelial cells. Int. J. Cancer 144(11):2795-2810.
  28. Chen, Y.L., Wu, W.L., Jang C.W., Yen, Y.C., Wang, S.H., Tsai, F.Y., Shen, Y.Y., Chen, Y.W.* (2019) Interferon-stimulated gene 15 modulates cell migration by interacting with Rac1 and contributes to lymph node metastasis of oral squamous cell carcinoma cells. Oncogene, 38(23):4480-4495.
  29. He, C.K., Chen, Y.W., Wang, S.H., Hsu, C.H. (2019) Hydrodynamic shuttling for deterministic high-efficiency multiple single-cell capture in a microfluidic chip. Lab on a chip, 19(8):1370.
  30. Hsing, E.W., Shiah, S.G., Peng, H.Y., Chen, Y.W., Chuu, C.P., Hsiao, J.R., Lyu, P.C., Chang, J.Y. (2019) TNF-α-induced miR-450a mediates TMEM182 expression to promote oral squamous cell carcinoma motility. PLoS One. 14(3):e0213463.
  31. He, C.K., Chen, Y.W., Wang, S.H., Hsu, C.H. (2019) Establishing Single-Cell Based Co-Cultures in a Deterministic Manner with a Microfluidic Chip. J Vis. Exp. Sep 27;(151). doi: 10.3791/60202.
  32. Chen, Y.L., Liu, K.J., Jang, C.W., Hsu, C.C, Yen, Y.C., Liu, Y.L., Chuang, T.H., Wang, S.S., Fu, Y.K., Kuo, C.C., Chen, Y.W.* (2019) ERK Activation Modulates Cancer Stemness and Motility of a Novel Mouse Oral Squamous Cell Carcinoma Cell Line. Cancers, 12(1):E61.
  33. Lin, C.M., Lin, L.W., Chen, Y.W., Ye, Y.L. (2020) The expression and prognostic impact of proinflammatory cytokines and their associations with carcinogens in oropharyngeal squamous cell carcinoma. Cancer Immunol Immunother. 2020 Jan 22. doi: 10.1007/s00262-020-02488-w.

[ Meeting Abstract ]

  1. Ya-Wen Chen*, Shiao-Chien Chu, Ze-Shiang Lin and Brian Lewis*. P16 enhances the migration phenotypes of hepatocellular carcinoma. Metastasis and the Tumor Microenivroment, MRS-AACR meeting, Philadelphia, Pennsylvania, 2010.
  2. Ya-Wen Chen, Yu-Ting Hung and Chen-Pin Chou*. Evaluation of blood flow in hepatocellular carcinoma: assessment with computed tomography perfusion parameters and circulating angiogenic factors. AACR 102nd annual meeting 2011, Orlando, Florida, 2011.
  3. Hsiao-Chien Chu, Ze-Shiang Lin, and Ya-Wen Chen*. P16 enhances the migration-associated phenotypes of hepatocellular carcinoma cells. NHRI Research Day, Miaoli, Taiwan, 2011.
  4. Yi-Chen Yen, Wei-Jhih Shiah and Ya-Wen Chen*. Characterization of metastasis-related phenotypes in oral cancer cell lines. NHRI Research Day, Maioli, Taiwan, 2011.
  5. Yi-Chen Yen, Shine-Gwo Shiah, Hsiao-Chien Chu, Yuan-Ming Hsu, Jenn-Ren Hsiao, Jang-Yang Chang, Chun-Ta Liao, Ann-Joy Cheng, Ya-Ching Lu and Ya-Wen Chen*. MiR-99a, down-regulated in oral cancers, suppresses cell migration by targeting to insulin-like growth factor I receptor signaling. Biomedical Research Symposium of National Health Research Institutes, Maioli, Taiwan, 2011.
  6. Ze-Shiang Lin, Hsiao-Chien Chu, Yi-Chen Yen and Ya-Wen Chen*. Klf4, frequently down-regulated in hepatocellular carcinoma, suppresses tumor growth and metastasis. Biomedical Research Symposium of National Health Research Institutes, Maioli, Taiwan, 2011.
  7. Hsiao-Chien Chu, Ze-Shiang Lin, Shine-Gwo Shiah, Brian C. Lewis and Ya-Wen Chen*. P16-enhanced the migration phenotypes in hepatocellular carcinoma cells is Rb-independent. AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, San Francisco, California, 2011.
  8. Ze-Shiang Lin, Hsiao-Chien Chu, Yi-Chen Yen and Ya-Wen Chen*. Klf4, frequently down-regulated in hepatocellular carcinoma, suppresses tumor growth and metastasis. 2012 The 27th Joint Annual Conference of Biomedical Science, National Defense Medical Center, Taipei, Taiwan, 2012.
  9. Yi-Chen Yen, Shine-Gwo Shiah, Jenn-Ren Hsiao, Jang-Yang Chang, and Ya-Wen Chen*. MiR-99a, down-regulated in oral cancers, suppresses cell migration by targeting to insulin-like growth factor I receptor signaling. 2012 The 27th Joint Annual Conference of Biomedical Science, National Defense Medical Center, Taipei, Taiwan, 2012.
  10. Yi-Chen Yen, Shine-Gwo Shiah, Hsiao-Chien Chu, Yuan-Ming Hsu, Jenn-Ren Hsiao, Jang-Yang Chang, Chun-Ta Liao, Ann-Joy Cheng, Ya-Ching Lu and Ya-Wen Chen*. MicroRNA-99a, a tumor suppressor in oral squamous cell carcinoma regulates insulin-like growth factors I receptor in a double-negative feedback loop. EORTC-NCI-AACR International Symposium on Molecular Targets and Cancer Therapeutics, Dublin, Ireland, 2012.
  11. Ya-Wen Chen*, Yi-Chen Yen, Shih Sheng Jiang, Wei-Hung Liu, Hsiao-Chien Chu. Isolation of oral squamous cell carcinoma cells with highly lymphatic metastasis. Japan Society of Clinical Oncology 51th Annual Meeting, Kyoto, Japan, 2013.
  12. Ya-Wen Chen*, Yi-Chen Yen, Jui-Ming Su, Shih Sheng Jiang, Wei-Hung Liu, Yin-Ying Shen, Wen-Chun Hung, Jang-Yang Chang, Jeffrey Shu-Ming Chang, Jenn-Ren Hsiao Isolation and characterization of oral squamous cell carcinoma cells with highly lymphatic metastasis. The 73rd Annual Meeting of Japanese Cancer Association, Yokohama, Japan, 2014
  13. Szu-Heng Liu, Yi-Chen Yen, Ssu-Han Wang, Ya-Wen Chen* Composition and functional analysis of the exosome derived from isogenic oral squamous cell carcinoma cells with different potentials of lymph node metastasis. SCBA 2015 Symposium, Taipei, Taiwan, 2015.
  14. Yi-Chen Yen, Shih-Sheng Jiang, Jeffrey S. Chang, Jenn-Ren Hsiao, Szu-Heng Liu, Jang-Yang Chang and Ya-Wen Chen* Insulin-like Growth Factor Binding Protein 3 Enhances Cell Migration in Oral Squamous Cell Carcinoma cells in IGF-independ manner. The 74th Annual Meeting of Japanese Cancer Association, Nagoya, Japan, 2015
  15. Ssu-Han Wang, Szu-Heng Liu, Yi-Chen Yen, Jeffrey S. Chang, Jenn-Ren Hsiao, Yin-Ying Shen, Jang-Yang Chang, Ya-Wen Chen* WNT5B modulates lymphatic metastasis in oral squamous cell carcinoma by inducing endothelial mesenchymal transition of lymphatic endothelial cells. The 74th Annual Meeting of Japanese Cancer Association, Nagoya, Japan, 2015
  16. Ya-Wen Chen, Gunn-Guang Liou, Shine-Gwo Shiah, Huay-Ben Pan, Hui-Hwa Tseng, Yu-Ting Hung, Chen-Pin Chou* Specific detection of CD133-positive tumor cells with iron oxide nanoparticle labeling using magnetic resonance imaging. The 74th Annual Meeting of Japanese Cancer Association, Nagoya, Japan, 2015.
  17. Ya-Wen Chen*, Ssu-Han Wang, Gunn-Guang Liou, Szu-Heng Liu, Jean Lu, Jang-Yang Chang Differential compositions and functions of the exosome derived from isogenic oral squamous cell carcinoma cells with different potentials of lympatic metastasis. ISREC-SCCL Symposium 2016: Horizons of Cancer Biology and Therapy, Laussane, Switzerland, 2016.
  18. Ssu-Han Wang, Jeffrey S. Chang, Jenn-Ren Hsiao, Yi-Chen Yen, Shih Sheng Jiang, Jang-Yang Chang, Ya-Wen Chen* WNT5B modulates in vitro lymphangiogenesis by inducing partial endothelial mesenchymal transition of lymphatic endothelial cells. The 75th Annual Meeting of Japanese Cancer Association, Yokohama, Japan, 2016.
  19. Ya-Wen Chen*, Gunn-Guang Liou, Ssu-Han Wang, Jeffrey S. Chang Laminin 2-rich exosomes enhance lymphangiogenesis via Integrin 3-mediated exosomal uptake. (selected oral presentation in International session” Cutting edge analysis of exosome in cancer metastasi” The 76th Annual Meeting of Japanese Cancer Association, Yokohama, Japan, 2017.
  20. Ya-Wen Chen, Tsung-Hsien Chuang, Ko-Jiuun Liu, Yi-Chen Yen, Ssu-Han Wang, Ching-Chuan Kuo Establishment and characterization of novel syngeneic oral squamous cell carcinoma mouse cell lines. The 77th Annual Meeting of Japanese Cancer Association, Osaka, Japan, 2018.
  21. Yu-Lin Chen, Wan-Lin Wu, Yi-Chen Yen, Ssu-Han Wang, Yin-Ying Shen, Ya-Wen Chen Interferon-stimulated gene 15 promotes cell migration through interacting with Rac1 and contribute to lymph node metastasis of oral squamous cell carcinoma cells. The 77th Annual Meeting of Japanese Cancer Association, Osaka, Japan, 2018.
  22. Ssu-Han Wang, Yu-Lin Chen, Yi-Chen Yen, Ya-Wen Chen Radio-sensitivity of IGFBP3 in oral squamous cell carcinoma cells. The 77th Annual Meeting of Japanese Cancer Association, Osaka, Japan, 2018.
  23. Ya-Wen Chen, Yu-Lin Chen, Yi-Chen Yen, Chuan-Wei Jang, Chung-Hsing Chen Ephrin A4-ephrin receptor A10 signaling promotes epithelial mesenchymal transition and spheroid formation in oral squamous cell carcinoma cells. (selected oral presentation in English oral session” Signal transduction of cancer cells (2)” The 78th Annual Meeting of Japanese Cancer Association, Kyoto, Japan, 2019.
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