PUBLICATIONS
- Krupple-like factor 10 deficiency, a novel mediated mechanism between AMP-activated protein kinase and hepatic de novo lipogenesis, results in nonalcoholic fatty liver progression. (2020 under review).
Hsuen-Wen Chang*, Hui-Ju Ch’ang*, Chia-Ling Hsieh, Wen-Chi Wu, Winston C.Y. Yu,Vincent H.S. Chang (equal contributing first author) - Phase III Study Comparing Adjuvant Gemcitabine versus Gemcitabine plus Chemoradiation in Curatively Resected Pancreatic Cancer – A Randomized Clinical Trial. (2020 under review).
Hui-Ju Ch’ang, Yen-Feng Chiu, Jen-Shi Chen, Chung-Pin Li, Ching-Liang Ho, MD; Yi-Ming Shyr, Wen-Chi Chou, Chun-Nan Yeh, Ruey-Kuen Hsieh, Yu-Lin Lin, Yu-Wen Tien, Tsann-Long Hwang, Yan-Shen Shan, Li-Tzong Chen. - Linoleic acid increases sirtuin 6 and ameliorates glycolysis and epithelial-mesenchymal transition of pancreatic cancer induced by loss of Krupple like factor 10 (2020 in submission)
Yi-Chih Tsai, Su-Liang Chen, Vincent HS Chang, Shu-Ling Peng, Winston CY Yu, Kung-Huang Cheng, Hui-Ju Chang*. (corresponding author) - Therapeutic Effect of Repurposed Temsirolimus in Lung Adenocarcinoma Model. Front Pharmacol. (SCI= 3.85, Pharmacology & Pharmacy, 59/267 Q1) 2018 Jul 24;9:778. doi: 10.3389/fphar.2018.00778. eCollection 2018.
Chang HW, Wu MJ, Lin ZM, Wang CY, Cheng SY, Lin YK, Chow YH, Ch’ang HJ, Chang VHS. - The role of consolidation chemo-radiotherapy in locally advanced pancreatic cancer receiving chemotherapy: an updated systematic review and meta-analysis. Cancer Res and Treat. (SCI= 3.36, Oncology 97/229, Q2) 2018 Apr;50(2):562-574. doi: 10.4143/crt.2017.105. Epub 2017 Jun 9. Review.
Jeffrey S. Chang, Yen-Feng Chiu, Jih-Chang Yu, Li-Tzong Chen, Hui-Ju Ch’ang*. (*corresponding author) - Characterization of a transgenic mouse model exhibiting spontaneous lung adenocarcinomas with a metastatic phenotype. PLoS One. (SCI=2.78, Multidisciplinary Sciences 24/69, Q2) 2017, Apr 18;12(4):e0175586. doi: 10.1371/journal.pone.0175586.
Chang HW, Lin ZM, Wu MJ, Wang LY, Chow YH, Jiang SS, Ch’ang HJ, Chang VH. - Krüpple-like Factor 10 Regulates Radio-sensitivity of Pancreatic Cancer via UV Radiation Resistance-Associated Gene. Radiother Oncol. (SCI= 5.25, Radiology, Nuclear Medicine & Medical Imaging 14/129, Q1) 2017, Mar;122(3):476-484, doi: 10.1016/j.radonc.2017.01.001. Epub 2017 Jan 16.
Vincent Hung-Shu Chang, Yi-Chih Tsai, Ya-Li Tsai, Shu-Ling Peng, Su-Liang Chen, Tsung Ming Chang, Winston Chun-Yuan Yu, Hui-Ju Ch’ang*. (* corresponding author) - A phase I clinical study of immunotherapy for advanced colorectal cancers using carcinoembryonic antigen-pulsed dendritic cells mixed with tetanus toxoid and subsequent IL-2 treatment.J Biomed Sci. (SCI=5.20, Medicine, Research & Experimental 20/136, Q1) 2016 Aug 24;23(1):64.
Liu KJ, Chao TY, Chang JY, Cheng AL, Ch’ang HJ, Kao WY, Wu YC, Yu WL, Chung TR, Whang-Peng J. - Bone marrow derived macrophages fuse with intestine stromal cells and contribute to chronic fibrosis after radiation. Radiother Oncol. (SCI= 5.25, Radiology, Nuclear Medicine & Medical Imaging 14/129 Q1) 2016 May;119: 250-8.
Yeh MH, Chang YH, Tsai YC, Chen SL, Huang TS, Chiu JF, Ch’ang HJ*. (*corresponding author) - Optimal combination of antiangiogenic therapy for hepatocellular carcinoma. World J. Hepatol. 2015 Aug 8;7(16):2029-40. Review.
Ch’ang HJ*(*corresponding author) - Perfusion parameters of dynamic contrast enhanced magnetic resonance imaging predict outcomes of hepatocellular carcinoma receiving radiotherapy with or without thalidomide. Hepatol Int (SCI=5.49, Gastroenterology & Hepatology 17/84 Q1) 2015 Apr;9(2):258-68.
Liang PC, Ch’ang HJ*, Hsu C, Chen LT, Shih TT, Liu TW (*corresponding author) - Circulating Cells Contribute to Cardiomyocyte Regeneration After Injury. Circulation Research(SCI=15.86, Hematology 2/73 Q1) 2015 Feb 13;116(4):633-41.
Wu JM, Hsueh YC, Ch’ang HJ, Luo CY, Wu LW, Nakauchi H, Hsieh PC. - Radiation Sensitization of Tumor Cells Induced by Shear Stress: The Roles of Integrins and FAK. Biochim Biophys Acta. (SCI=4.74, Biochemistry; Molecular Biology 55/298 Q1) 2014 Sep;1843(9):2129-37.
Luo CW, Wu CC, Ch’ang HJ* (*corresponding author) - Destabilization of KLF10, a tumor suppressor, relies on thr93 phosphorylation and isomerase association. Biochim Biophys Acta. (SCI=5.13, Biochemistry & Molecular Biology 55/293 Q1) 2013 Dec;1833(12):3035-45.
Hwang YC, Yang CH, Lin CH, Ch’ang HJ, Chang VH, Yu WC. - Bone marrow transplantation rescues intestinal mucosa after whole body radiation via paracrine mechanisms.Radiother Oncol. (SCI= 5.25, Radiology, Nuclear Medicine & Medical Imaging 14/129 Q1) 2012 Dec;105(3):371-7.
Chang YH, Lin LM, Lou CW, Chou CK, Ch’ang HJ*(*corresponding author). - Krüppel-like factor 10 Expression as a Prognostic Indicator for Pancreatic Adenocarcinoma, American Journal of Pathology (SCI 3.76, Pathology 14/76 Q1) 2012 Aug;181(2):423-30.
Vincent H. S. Chang , Pei-Yi Chu, Shu-Ling Peng, Tsui-Lien Mao, Yan-Shen Shan, Ching-Fang Hsu, Chun-Yu Lin, Kelvin K.C. Tsai, Winston C. Y. Yu*, Hui-Ju Ch’ang*(*corresponding author) - Bone marrow Transplantation Enhances Trafficking of Host Derived Myelomonocytic Cells that Rescue Intestinal Mucosa after Whole Body Radiation, Radiotherapy and Oncology (SCI= 5.25, Radiology, Nuclear Medicine & Medical Imaging 14/129 Q1) 2012 Sep;104(3):401-7.
Hui-Ju Ch’ang*, Li-Mei Lin, Pu-Yuan Chang,1Chi-Wen Luo,Ya-Hui Chang, Chuan-Kai Chou, Helen H. Chen. (*corresponding author) - Phase II Study of Concomitant Thalidomide during Radiotherapy for Hepatocellular Carcinoma. Int. J. Radiat. Oncol. Biol. Phys. (SCI=6.20; Radiology, Nuclear Medicine & Medical Imaging: 8/129 Q1) 2012 Feb 1;82(2):817-25.
Hui-Ju Ch’ang*, Chiun Hsu, Chien-Hung Chen, Ya-Hui Chang, Jeffrey Shuming Chang, Li-Tzong Chen. (*corresponding author) - Induction Chemotherapy with Gemcitabine, Oxaliplatin, and 5-Fluorouracil/Leucovorin Followed by Concomitant Chemoradiotherapy in Patients with Locally Advanced Pancreatic Cancer: A Taiwan Cooperative Oncology Group Phase II Study. Int. J. Radiat. Oncol. Biol. Phys. (SCI=6.20; Radiology, Nuclear Medicine & Medical Imaging: 8/129 Q1) 2011; 81(5):e749-57.
Hui-Ju Ch’ang, Yu-Lin Lin, Hsiu-Po Wang, Yen-Feng Chiu, Ming-Chu Chang, , Chih-Hung Hsu, Yu-Wen Tien, Jen-Shi Chen, Ruey-Kuen Hsieh, Pin-Wen Lin, Yan-Shen Shan, Ann-Lii Cheng, Jang-Yang Chang, Jacqueline Whang-Peng, Tsann-Long Hwang*, Li-Tzong Chen*. - Updates in the Management of Locally Advanced Pancreatic Cancer. Therapeutic Radiology and Oncology. 2011; 18(3) 215-224.
Hui-Ju Ch’ang*, Helen HW Chen, Li-Tzong Chen.(*corresponding author) - Phase II Study of Biweekly Gemcitabine Followed by Oxaliplatin and Simplified 48-hr Infusion of 5-Fluorouracil / Leucovorin (GOFL) for Advanced Pancreatic Cancer. Cancer Chemo and Pharmacol. (SCI=3.00; Pharmacology & Pharmacy: 101/267 Q2) 2009; 64(6):1173-9.
Hui-Ju Ch’ang, Chin-Lun Huang, Hsiu-Po Wang, Her-Shyong Shiah, Ming-Chu Chang, Chang-Ming Jan, Jen-Shi Chen, Yu-Wen Tien, Tsann-Long Hwang, Jaw-Town Lin, Ann-Lii Cheng, Li-Tzong Chen* - Dynamic MRI Signals in the Second Week of Radiotherapy Relate to Treatment Outcomes of Hepatocellular Carcinoma – A Preliminary Result, Liver International (SCI=5.54; GASTROENTEROLOGY & HEPATOLOGY: 16/84, Q1) 2007; 27(4):516-28.
Po-Chin Liang,* Hui-Ju Ch’ang,* Chiun Hsu, Shuo Shuo Tseng, Tiffany T.F. Shih, Tsang Wu Liu, (*equal contribution) - Phase I Study of Biweekly Gemcitabine followed by Oxaliplatin and Simplified 48-hr infusion of Fluorouracil / Leucovorin (GOFL) for Advanced Pancreatic Cancer. J Gastroenterol Hepatol. (SCI=3.63; GASTROENTEROLOGY & HEPATOLOGY: 30/84, Q2) 2006; 21(5): 874-9.
Hui-Ju Ch’ang*, Chuan-Cheng, Wang*, Ann-Lii Cheng, Chiun Hsu, Yen-Shen Lu, Ming-Chu Chang, Jaw-Town Lin, Hsiu-Po Wang, Tsang-Wu Liu, Jang-Yang Chang, Jacqueline Whang-Peng, Li-Tzong Chen.(*equal contribution) - ATM Regulates Target Switching to Escalating Doses of Radiation in the Intestines. Nature Medicine (SCI=32.62, Medicine, Research & Experimental 1/133, Q1) 2005; 11(5) 484-490.
Hui-Ju Ch’ang, Jerzy G. Maj, Francois Paris, H. Rosie Xing, Jianjun Zhang, Jean-Philip Truman, Carlos Cardon-Cardo, Adriana Haimovitz Friedman, Richard Kolesnick and Zvi Fuks. - Preoperative Concurrent Chemotherapy and Radiotherapy in Rectal Cancer Patients. J. Formos. Med. Assoc. (SCI=2.844, Medicine, General & Internal, 35/160, Q1) 1998; 97: 32-7.
Hui-Ju Ch’ang, James J.M. Jian, Skye H. Cheng, Mei-Ching Liu, Shuh-Yan Leu, Feng-Ming Wang, Stella Y.C. Tsai, Mei-Hua Tsao, Hshu-Hhing Lin, Andrew T. Huang, and Juei-Law Sung. - Angioimmunoblastic Lymphadenopathy with Dysproteinemia- Lack of a Prognostic Value of Clear Cell Morphology. Oncology (SCI=2028, Oncology 165/229, Q3) 1997; 54; 193-8.
Hui-Ju Ch’ang, Ih-Jen Su, Chi-Long Chen, I-Pieng Chiang, Yao-Chang Chen, Chiu-Hwa Wang, Ann-Lii Cheng. - Postoperative Concurrent Chemotherapy and Radiotherapy for Resectable Locally advanced Gastric Cancer Patients- A preliminary Report. Therapeutic Radiology and Oncology 1997; 4(3); 195-201.
Hui-Ju Ch’ang, Skye H. Cheng, Mei-Chin Liu, James J.M. Jian, Chii-Ming Chen. - Comparison of Clinical and Biologic Features between Myeloid and Lymphoid Transformation of Philadelphia Chromosome Positive Chronic Myeloid Leukemia. Cancer Genet. Cytogenet. 1993; 71; 87-93 (SCI=1.93, Oncology 135/197, Q3).
Hui-Ju Ch’ang, Hwei-Fang Tien, Chiu-Hwa Wang, Sou-Ming Chuang, Yao Chang Chen.
Abstracts:
- Linoleic acid elevates Sirtuin 6 expression, and modulates glycolysis and epithelial-mesenchymal transition of pancreatic cancer with loss of Krüpple like factor 10. 2019 AACR Pancreatic Cancer Conference Abstract C11.
Hui-Ju Ch’ang*, Yi-Chih Tsai, Su-Liang Chen, and Vincent HS Chang. - Randomized Phase III Study Comparing Adjuvant Gemcitabine vs. Gemcitabine plus Chemoradiation in Curatively Resected Pancreatic Cancer – Taiwan Cooperative Oncology Group T3207 study. 2018 ESMO annual congress Abstract 626PD.
H.J. Ch’ang*, Y.F. Chiu, J.S. Chen, C.P. Li, C.L. Ho, Y.M. Shyr, W.C. Chiou, C.N. Yeh, R.K Hsieh, Y.L Lin, Y.W. Tien, T.L. Hwang, Y.S. Shan, L.T. Chen (*corresponding author). - Loss of Krüpple Like Factor 10 Enhances Epithelial Mesenchymal Transition and Glycolysis of Pancreatic Cancer by modulating SIRT6. 2018 Taiwan Cooperative Oncology Annual Meeting.
Yi-Chih Tsai, Su-Liang Chen, Vincent HS Chang, and Hui-Ju Ch’ang*(*corresponding author). - Tumor-macrophage fusion hybrids contribute to radiation-induced progression of pancreatic cancer.2017 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics. Abst No A209.
Baskaran Rathinasamy, Chun Jen Wang, Ssu-Pei Wan, Hui-Ju Ch’ang*(*corresponding author). - Loss of Krupple Like Factor 10 Enhanced Epithelial Mesenchymal Transition of Pancreatic Cancer by Modulating Glucose Metabolism via Sirt 6 and PKM2. Cancer Res 2016;76(14 Suppl): AACR annual meeting Abstract nr 701.
Yi-Chih Tsai, Su-Liang Chen, Vincent HS Chang, and Hui-Ju Ch’ang*. (* corresponding author) - Tumor-Macrophage Fusion Hybrids Contribute to Tumor Radiation Resistance via Epithelial Mesenchymal Transition. 2015 EACR meeting abstract 563.
Hui-Ju Ch’ang*, Hsun-Hua Yeh, Ya-Hui Chang, Ya-Li Tsai, Tsung Ming Chang. (corresponding author) - Krüppel-like factor 10 Modulates Radio-sensitivity by Transcriptionally Regulating UV Radiation Resistance Associated Gene in Pancreatic Cancer. Ann Oncol suppl 2014 Oct. ESMO annual meeting abstract 5590.
Ch’ang HJ*, Tsai YL, Chang VH, Yu WC, Peng SL, Shan YS, Li CP. (*corresponding author) - Depleting macrophage or blocking cell fusion machinery ameliorates intestine fibrosis after radiation. AACR 2014 annual meeting abstract 3959/24.
Ya-Hui Chang, Hui-Ju Ch’ang*, Li-Mei Lin. (* corresponding author) - Strategies Targeting Fusion Machinery of Bone Marrow Derived Macrophage May Ameliorate Intestinal Fibrosis after Radiation. European Journal of Cancer 2013, 49 (suppl 2), p S103, 521.
Hui-Ju Ch’ang*, Ya-Hui Chang, Li-Mei Lin. (*corresponding author) - Fusion between Bone Marrow and Intestine Stromal Cells Contributes to Intestine Fibrosis after Radiation. Radiotherapy and Oncology, Mar 2012: 102, S66-67.
Hui-Ju Ch’ang*, Ya-Hui Chang, Li-Mei Lin .(*corresponding author) - Radiation Sensitization of Tumor Cells Induced by Shear Stress: Roles of Integrin Beta-1 and FAK. Annals of Oncology Supplement: (011 #1.165.
Hui-Ju Ch’ang*, Chi-Wen Luo, Chia-Ching Wu. (*corresponding author) - Shear stress radiosensitizes colon cancer cells by downregulating FAK via integrin β1. 102th AACR annual meeting (2011) Cancer Research 2011, 71 (8 suppl):569.
Chi-Wen Luo, Chia-Ching Wu, Hui-Ju Mandy Ch’ang*. (*corresponding author) - Loss of Immunolabeling of Kruppel Like Factor 10 is Associated with Advanced Stage and Rapid Progression of Pancreatic Cancer. Annals of Oncology Oct 2010: 21(S8), p73, 197P.
Hui-Ju Ch’ang*, Hung-Shu Chang, Pei-Yi Chu, Tsui-Lien Mao, Winston C.Y. Yu. (* corresponding author) - Local radiotherapy suppresses granulocyte colony-stimulating factor induced tumor angiogenesis and metastasis. Cancer Research: 100th American Association of Cancer Research 2009 #711.
Pu-Yuan Chang, Li-Mei Lin, Helen HW Chen, Chuan-Kai Chou, Hui-Ju Mandy Ch’ang*. (*corresponding author) - A phase II study of gemcitabine-based chemoradiotherapy (CCRT) after triplet induction chemotherapy (ICT) for locally advanced pancreatic cancer (LAPC) – a Taiwan Cooperative Oncology Group (TCOG) study. J. Clin. Oncol: American Society of Clinical Oncology 2009 # e15562.
H. Ch’ang, T. Hwang, H. Wang, M. Chang, Y. Tien, J. Chen, R. Hsieh, P. Lin, Y. Shan, A. Cheng, L. Chen. - Bone Marrow Enhances Intestinal Stromal Cell Proliferation and Protects Intestine from Radiation Damage Through Paracrine Mechanisms. Gordon Research Conference- Radiation Oncology 2008 #10.
Hui-Ju Ch’ang*, Pu-Yuan Chang, Li-Mei Lin, Ya-Chiun Hsu, I-Min Jen, Helen HW Chen. (* corresponding author) - Phase II Study of Biweekly Gemcitabine Followed by Oxaliplatin and Simplified 48-hr Infusion of 5-Fluorouracil/Leucovorin (GOFL) in Advanced Pancreatic Cancer.J. Clin. Oncol.: ASCO-Gastrointestinal Cancer Symposium 2008 # 221.
Li-Tzong Chen, Hui-Ju Ch’ang, Chin-Lun Huang, Hsiu-Po Wang, Her-Shyong Shiah, Ming-Chu Chang, Chang-Ming Jan, Jen-Shi Chen, Yu-Wen Tien, Tsann-Long Hwang, Jaw-Town Lin, Ann-Lii Cheng. - Safety-profile of gemcitabine-based chemoradiotherapy (CRT) after triplet induction chemotherapy (CT) in locally advanced pancreatic cancer (LAPC): Preliminary data from Taiwan Cooperative Oncology Group (TCOG) T1204 study. J. Clin. Oncol. ASCO-Gastrointestinal Cancer Symposium 2008 # 156.
Li-Tzong Chen, Hui-Ju Ch’ang, Chin-Lun Huang, Hsiu-Po Wang, Her-Shyong Shiah, Ming-Chu Chang, Chang-Ming Jan, Jen-Shi Chen, Yu-Wen Tien, Tsann-Long Hwang, Jaw-Town Lin, Ann-Lii Cheng. - Bone marrow cells regulate intestinal repair after radiation via differentiation independent mechanisms. Cancer Research: AACR 2006 # LB-221.
HJ Ch’ang*, LM Lin, HC Chang, C Lan, YC Hsu, YM Jen, JM Liu, J Whang-Peng. (* corresponding author) - Phase I/II Study of Biweekly Gemcitabine followed by Oxaliplatin and Simplied 48-hr infusion of Fluorouracil / Leucovorin (GOFL) in Pancreatic Cancer J. Clin. Oncol.: ASCO- Gastrointestinal Cancer Symposium 2005 # 147.
L. Chen, H. Ch’ang, M. Chang, C. Wang, A. Cheng, C. Hsu, C. Jan, S. Chen, T. Liu, J. Chang. - Prediction of Radiotherapy Outcome Using Dynamic Contrast Enhanced MRI of Hepatocellular Carcinoma. Radiat & Oncol: European Society of Therapeutic Radiation Oncology 2004 # 644.
Ch’ang HJ*, Lien Po-Chin C, Tseng Shou Shou, Hsu C, Shih TTF. (* corresponding author) - Gastrointestinal tract tissue repair after radiation damage is associated with bone marrow reserve. Cancer Research: AACR 2003 # LB112.
Hui-Ju Ch’ang*, Limei Lin, Shiu-Chen Jeng, Chieh Lan, Jacqueline M. Liu. (* corresponding author) - Target Switching in Radiation Induced Gastrointestinal Death of Mice. Cancer Research: AACR 2002 #101051.
Hui-Ju Mandy Ch’ang, Francois Paris, Adriana Haimovitz-Friedman, Carlos Cordon-Cardo, Zvi Fuks, Richard Kolesnick. - Potentiation of Taxol Cytotoxicity by Human Urine Extract in MCF7/ADR Cells. Cancer Research: AACR 1999 #4380.
Hui-Ju Ch’ang, S.E. Chuang, F.C. Liu, Y.F. Chen, C.W. Hsieh, G.M. Lai. - Preoperative Concurrent Chemotherapy and Radiotherapy in Rectal Cancer Patients. 16th Annual Chinese Cancer Society Conference 1997.
Hui-Ju Ch’ang, James J.M. Jian, Skye H. Cheng, Mei-Ching Liu, Shuh-Yan Leu, Feng-Ming Wang, Stella Y.C. Tsai, Mei-Hua Tsao, Hshu-Hhing Lin, Andrew T. Huang, and Juei-Law Sung. - Postoperative Concurrent Chemotherapy and Radiotherapy for Resectable Locally Advanced Gastric Cancer Patients – A Preliminary Report. 15th Annual Chinese Cancer Society Conference 1996.
Hui-Ju Ch’ang, Skye H. Cheng, Mei-Chin Liu, James J.M. Jian, Chii-Ming Chen. - Preoperative Concurrent Chemoradiotherapy with Continuous Low Dose Infusion of 5-Fluorouracil and Daily Cisplatinum Injection for Locoregional Esophageal Cancer- A Preliminary Report. 14th Annual Chinese Cancer Society Conference 1995.
Hui-Ju Ch’ang, Louis Tak Lui, K.H. Yeh, Y.C. Lee, A.L. Cheng. - Comparison of Clinical and Biologic Features between Myeloid and Lymphoid Transformation of Philadelphia Chromosome Positive Chronic Myeloid Leukemia. 84th Chinese Hemotology Society Conference 1993.
Hui-Ju Ch’ang, Hwei-Fang Tien, Chiu-Hwa Wang, Sou-Ming Chuang, Yao Chang Chen. - Characterization of Philadelphia Chromosome Positive Acute Leukemia. 80th Chinese Hemotology Society Conference 1992.
Hwei-Fang Tien,Hui-Ju Ch’ang, Chiu-Hwa Wang, Sou-Ming Chuang, Yao Chang Chen.
