常慧如 副研究員-論文

PUBLICATIONS
  1. Krupple-like factor 10 deficiency, a novel mediated mechanism between AMP-activated protein kinase and hepatic de novo lipogenesis, results in nonalcoholic fatty liver progression. (2020 under review).
    Hsuen-Wen Chang*, Hui-Ju Ch’ang*, Chia-Ling Hsieh, Wen-Chi Wu, Winston C.Y. Yu,Vincent H.S. Chang (equal contributing first author)
  2. Phase III Study Comparing Adjuvant Gemcitabine versus Gemcitabine plus Chemoradiation in Curatively Resected Pancreatic Cancer – A Randomized Clinical Trial. (2020 under review).
    Hui-Ju Ch’ang, Yen-Feng Chiu, Jen-Shi Chen, Chung-Pin Li, Ching-Liang Ho, MD; Yi-Ming Shyr, Wen-Chi Chou, Chun-Nan Yeh, Ruey-Kuen Hsieh, Yu-Lin Lin, Yu-Wen Tien, Tsann-Long Hwang, Yan-Shen Shan, Li-Tzong Chen.
  3. Linoleic acid increases sirtuin 6 and ameliorates glycolysis and epithelial-mesenchymal transition of pancreatic cancer induced by loss of Krupple like factor 10 (2020 in submission)
    Yi-Chih Tsai, Su-Liang Chen, Vincent HS Chang, Shu-Ling Peng, Winston CY Yu, Kung-Huang Cheng, Hui-Ju Chang*. (corresponding author)
  4. Therapeutic Effect of Repurposed Temsirolimus in Lung Adenocarcinoma Model. Front Pharmacol. (SCI= 3.85, Pharmacology & Pharmacy, 59/267 Q1) 2018 Jul 24;9:778. doi: 10.3389/fphar.2018.00778. eCollection 2018.
    Chang HW, Wu MJ, Lin ZM, Wang CY, Cheng SY, Lin YK, Chow YH, Ch’ang HJ, Chang VHS.
  5. The role of consolidation chemo-radiotherapy in locally advanced pancreatic cancer receiving chemotherapy: an updated systematic review and meta-analysis. Cancer Res and Treat. (SCI= 3.36, Oncology 97/229, Q2) 2018 Apr;50(2):562-574. doi: 10.4143/crt.2017.105. Epub 2017 Jun 9. Review.
    Jeffrey S. Chang, Yen-Feng Chiu, Jih-Chang Yu, Li-Tzong Chen, Hui-Ju Ch’ang*. (*corresponding author)
  6. Characterization of a transgenic mouse model exhibiting spontaneous lung adenocarcinomas with a metastatic phenotype. PLoS One. (SCI=2.78, Multidisciplinary Sciences 24/69, Q2) 2017, Apr 18;12(4):e0175586. doi: 10.1371/journal.pone.0175586.
    Chang HW, Lin ZM, Wu MJ, Wang LY, Chow YH, Jiang SS, Ch’ang HJ, Chang VH.
  7. Krüpple-like Factor 10 Regulates Radio-sensitivity of Pancreatic Cancer via UV Radiation Resistance-Associated Gene. Radiother Oncol. (SCI= 5.25, Radiology, Nuclear Medicine & Medical Imaging 14/129, Q1) 2017, Mar;122(3):476-484, doi: 10.1016/j.radonc.2017.01.001. Epub 2017 Jan 16.
    Vincent Hung-Shu Chang, Yi-Chih Tsai, Ya-Li Tsai, Shu-Ling Peng, Su-Liang Chen, Tsung Ming Chang, Winston Chun-Yuan Yu, Hui-Ju Ch’ang*. (* corresponding author)
  8. A phase I clinical study of immunotherapy for advanced colorectal cancers using carcinoembryonic antigen-pulsed dendritic cells mixed with tetanus toxoid and subsequent IL-2 treatment.J Biomed Sci. (SCI=5.20, Medicine, Research & Experimental 20/136, Q1) 2016 Aug 24;23(1):64.
    Liu KJ, Chao TY, Chang JY, Cheng AL, Ch’ang HJ, Kao WY, Wu YC, Yu WL, Chung TR, Whang-Peng J.
  9. Bone marrow derived macrophages fuse with intestine stromal cells and contribute to chronic fibrosis after radiation. Radiother Oncol. (SCI= 5.25, Radiology, Nuclear Medicine & Medical Imaging 14/129 Q1) 2016 May;119: 250-8.
    Yeh MH, Chang YH, Tsai YC, Chen SL, Huang TS, Chiu JF, Ch’ang HJ*. (*corresponding author)
  10. Optimal combination of antiangiogenic therapy for hepatocellular carcinoma. World J. Hepatol. 2015 Aug 8;7(16):2029-40. Review.
    Ch’ang HJ*(*corresponding author)
  11. Perfusion parameters of dynamic contrast enhanced magnetic resonance imaging predict outcomes of hepatocellular carcinoma receiving radiotherapy with or without thalidomide. Hepatol Int (SCI=5.49, Gastroenterology & Hepatology 17/84 Q1) 2015 Apr;9(2):258-68.
    Liang PC, Ch’ang HJ*, Hsu C, Chen LT, Shih TT, Liu TW (*corresponding author)
  12. Circulating Cells Contribute to Cardiomyocyte Regeneration After Injury. Circulation Research(SCI=15.86, Hematology 2/73 Q1) 2015 Feb 13;116(4):633-41.
    Wu JM, Hsueh YC, Ch’ang HJ, Luo CY, Wu LW, Nakauchi H, Hsieh PC.
  13. Radiation Sensitization of Tumor Cells Induced by Shear Stress: The Roles of Integrins and FAK. Biochim Biophys Acta. (SCI=4.74, Biochemistry; Molecular Biology 55/298 Q1) 2014 Sep;1843(9):2129-37.
    Luo CW, Wu CC, Ch’ang HJ* (*corresponding author)
  14. Destabilization of KLF10, a tumor suppressor, relies on thr93 phosphorylation and isomerase association. Biochim Biophys Acta. (SCI=5.13, Biochemistry & Molecular Biology 55/293 Q1) 2013 Dec;1833(12):3035-45.
    Hwang YC, Yang CH, Lin CH, Ch’ang HJ, Chang VH, Yu WC.
  15. Bone marrow transplantation rescues intestinal mucosa after whole body radiation via paracrine mechanisms.Radiother Oncol. (SCI= 5.25, Radiology, Nuclear Medicine & Medical Imaging 14/129 Q1) 2012 Dec;105(3):371-7.
    Chang YH, Lin LM, Lou CW, Chou CK, Ch’ang HJ*(*corresponding author).
  16. Krüppel-like factor 10 Expression as a Prognostic Indicator for Pancreatic Adenocarcinoma, American Journal of Pathology (SCI 3.76, Pathology 14/76 Q1) 2012 Aug;181(2):423-30.
    Vincent H. S. Chang , Pei-Yi Chu, Shu-Ling Peng, Tsui-Lien Mao, Yan-Shen Shan, Ching-Fang Hsu, Chun-Yu Lin, Kelvin K.C. Tsai, Winston C. Y. Yu*, Hui-Ju Ch’ang*(*corresponding author)
  17. Bone marrow Transplantation Enhances Trafficking of Host Derived Myelomonocytic Cells that Rescue Intestinal Mucosa after Whole Body Radiation, Radiotherapy and Oncology (SCI= 5.25, Radiology, Nuclear Medicine & Medical Imaging 14/129 Q1) 2012 Sep;104(3):401-7.
    Hui-Ju Ch’ang*, Li-Mei Lin, Pu-Yuan Chang,1Chi-Wen Luo,Ya-Hui Chang, Chuan-Kai Chou, Helen H. Chen. (*corresponding author)
  18. Phase II Study of Concomitant Thalidomide during Radiotherapy for Hepatocellular Carcinoma. Int. J. Radiat. Oncol. Biol. Phys. (SCI=6.20; Radiology, Nuclear Medicine & Medical Imaging: 8/129 Q1) 2012 Feb 1;82(2):817-25.
    Hui-Ju Ch’ang*, Chiun Hsu, Chien-Hung Chen, Ya-Hui Chang, Jeffrey Shuming Chang, Li-Tzong Chen. (*corresponding author)
  19. Induction Chemotherapy with Gemcitabine, Oxaliplatin, and 5-Fluorouracil/Leucovorin Followed by Concomitant Chemoradiotherapy in Patients with Locally Advanced Pancreatic Cancer: A Taiwan Cooperative Oncology Group Phase II Study. Int. J. Radiat. Oncol. Biol. Phys. (SCI=6.20; Radiology, Nuclear Medicine & Medical Imaging: 8/129 Q1) 2011; 81(5):e749-57.
    Hui-Ju Ch’ang, Yu-Lin Lin, Hsiu-Po Wang, Yen-Feng Chiu, Ming-Chu Chang, , Chih-Hung Hsu, Yu-Wen Tien, Jen-Shi Chen, Ruey-Kuen Hsieh, Pin-Wen Lin, Yan-Shen Shan, Ann-Lii Cheng, Jang-Yang Chang, Jacqueline Whang-Peng, Tsann-Long Hwang*, Li-Tzong Chen*.
  20. Updates in the Management of Locally Advanced Pancreatic Cancer. Therapeutic Radiology and Oncology. 2011; 18(3) 215-224.
    Hui-Ju Ch’ang*, Helen HW Chen, Li-Tzong Chen.(*corresponding author)
  21. Phase II Study of Biweekly Gemcitabine Followed by Oxaliplatin and Simplified 48-hr Infusion of 5-Fluorouracil / Leucovorin (GOFL) for Advanced Pancreatic Cancer. Cancer Chemo and Pharmacol. (SCI=3.00; Pharmacology & Pharmacy: 101/267 Q2) 2009; 64(6):1173-9.
    Hui-Ju Ch’ang, Chin-Lun Huang, Hsiu-Po Wang, Her-Shyong Shiah, Ming-Chu Chang, Chang-Ming Jan, Jen-Shi Chen, Yu-Wen Tien, Tsann-Long Hwang, Jaw-Town Lin, Ann-Lii Cheng, Li-Tzong Chen*
  22. Dynamic MRI Signals in the Second Week of Radiotherapy Relate to Treatment Outcomes of Hepatocellular Carcinoma – A Preliminary Result, Liver International (SCI=5.54; GASTROENTEROLOGY & HEPATOLOGY: 16/84, Q1) 2007; 27(4):516-28.
    Po-Chin Liang,* Hui-Ju Ch’ang,* Chiun Hsu, Shuo Shuo Tseng, Tiffany T.F. Shih, Tsang Wu Liu, (*equal contribution)
  23. Phase I Study of Biweekly Gemcitabine followed by Oxaliplatin and Simplified 48-hr infusion of Fluorouracil / Leucovorin (GOFL) for Advanced Pancreatic Cancer. J Gastroenterol Hepatol. (SCI=3.63; GASTROENTEROLOGY & HEPATOLOGY: 30/84, Q2) 2006; 21(5): 874-9.
    Hui-Ju Ch’ang*, Chuan-Cheng, Wang*, Ann-Lii Cheng, Chiun Hsu, Yen-Shen Lu, Ming-Chu Chang, Jaw-Town Lin, Hsiu-Po Wang, Tsang-Wu Liu, Jang-Yang Chang, Jacqueline Whang-Peng, Li-Tzong Chen.(*equal contribution)
  24. ATM Regulates Target Switching to Escalating Doses of Radiation in the Intestines. Nature Medicine (SCI=32.62, Medicine, Research & Experimental 1/133, Q1) 2005; 11(5) 484-490.
    Hui-Ju Ch’ang, Jerzy G. Maj, Francois Paris, H. Rosie Xing, Jianjun Zhang, Jean-Philip Truman, Carlos Cardon-Cardo, Adriana Haimovitz Friedman, Richard Kolesnick and Zvi Fuks.
  25. Preoperative Concurrent Chemotherapy and Radiotherapy in Rectal Cancer Patients. J. Formos. Med. Assoc. (SCI=2.844, Medicine, General & Internal, 35/160, Q1) 1998; 97: 32-7.
    Hui-Ju Ch’ang, James J.M. Jian, Skye H. Cheng, Mei-Ching Liu, Shuh-Yan Leu, Feng-Ming Wang, Stella Y.C. Tsai, Mei-Hua Tsao, Hshu-Hhing Lin, Andrew T. Huang, and Juei-Law Sung.
  26. Angioimmunoblastic Lymphadenopathy with Dysproteinemia- Lack of a Prognostic Value of Clear Cell Morphology. Oncology (SCI=2028, Oncology 165/229, Q3) 1997; 54; 193-8.
    Hui-Ju Ch’ang, Ih-Jen Su, Chi-Long Chen, I-Pieng Chiang, Yao-Chang Chen, Chiu-Hwa Wang, Ann-Lii Cheng.
  27. Postoperative Concurrent Chemotherapy and Radiotherapy for Resectable Locally advanced Gastric Cancer Patients- A preliminary Report. Therapeutic Radiology and Oncology 1997; 4(3); 195-201.
    Hui-Ju Ch’ang, Skye H. Cheng, Mei-Chin Liu, James J.M. Jian, Chii-Ming Chen.
  28. Comparison of Clinical and Biologic Features between Myeloid and Lymphoid Transformation of Philadelphia Chromosome Positive Chronic Myeloid Leukemia. Cancer Genet. Cytogenet. 1993; 71; 87-93 (SCI=1.93, Oncology 135/197, Q3).
    Hui-Ju Ch’ang, Hwei-Fang Tien, Chiu-Hwa Wang, Sou-Ming Chuang, Yao Chang Chen.

Abstracts:

  1. Linoleic acid elevates Sirtuin 6 expression, and modulates glycolysis and epithelial-mesenchymal transition of pancreatic cancer with loss of Krüpple like factor 10. 2019 AACR Pancreatic Cancer Conference Abstract C11.
    Hui-Ju Ch’ang*, Yi-Chih Tsai, Su-Liang Chen, and Vincent HS Chang.
  2. Randomized Phase III Study Comparing Adjuvant Gemcitabine vs. Gemcitabine plus Chemoradiation in Curatively Resected Pancreatic Cancer – Taiwan Cooperative Oncology Group T3207 study. 2018 ESMO annual congress Abstract 626PD.
    H.J. Ch’ang*, Y.F. Chiu, J.S. Chen, C.P. Li, C.L. Ho, Y.M. Shyr, W.C. Chiou, C.N. Yeh, R.K Hsieh, Y.L Lin, Y.W. Tien, T.L. Hwang, Y.S. Shan, L.T. Chen (*corresponding author).
  3. Loss of Krüpple Like Factor 10 Enhances Epithelial Mesenchymal Transition and Glycolysis of Pancreatic Cancer by modulating SIRT6. 2018 Taiwan Cooperative Oncology Annual Meeting.
    Yi-Chih Tsai, Su-Liang Chen, Vincent HS Chang, and Hui-Ju Ch’ang*(*corresponding author).
  4. Tumor-macrophage fusion hybrids contribute to radiation-induced progression of pancreatic cancer.2017 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics. Abst No A209.
    Baskaran Rathinasamy, Chun Jen Wang, Ssu-Pei Wan, Hui-Ju Ch’ang*(*corresponding author).
  5. Loss of Krupple Like Factor 10 Enhanced Epithelial Mesenchymal Transition of Pancreatic Cancer by Modulating Glucose Metabolism via Sirt 6 and PKM2. Cancer Res 2016;76(14 Suppl): AACR annual meeting Abstract nr 701.
    Yi-Chih Tsai, Su-Liang Chen, Vincent HS Chang, and Hui-Ju Ch’ang*. (* corresponding author)
  6. Tumor-Macrophage Fusion Hybrids Contribute to Tumor Radiation Resistance via Epithelial Mesenchymal Transition. 2015 EACR meeting abstract 563.
    Hui-Ju Ch’ang*, Hsun-Hua Yeh, Ya-Hui Chang, Ya-Li Tsai, Tsung Ming Chang. (corresponding author)
  7. Krüppel-like factor 10 Modulates Radio-sensitivity by Transcriptionally Regulating UV Radiation Resistance Associated Gene in Pancreatic Cancer. Ann Oncol suppl 2014 Oct. ESMO annual meeting abstract 5590.
    Ch’ang HJ*, Tsai YL, Chang VH, Yu WC, Peng SL, Shan YS, Li CP. (*corresponding author)
  8. Depleting macrophage or blocking cell fusion machinery ameliorates intestine fibrosis after radiation. AACR 2014 annual meeting abstract 3959/24.
    Ya-Hui Chang, Hui-Ju Ch’ang*, Li-Mei Lin. (* corresponding author)
  9. Strategies Targeting Fusion Machinery of Bone Marrow Derived Macrophage May Ameliorate Intestinal Fibrosis after Radiation. European Journal of Cancer 2013, 49 (suppl 2), p S103, 521.
    Hui-Ju Ch’ang*, Ya-Hui Chang, Li-Mei Lin. (*corresponding author)
  10. Fusion between Bone Marrow and Intestine Stromal Cells Contributes to Intestine Fibrosis after Radiation. Radiotherapy and Oncology, Mar 2012: 102, S66-67.
    Hui-Ju Ch’ang*, Ya-Hui Chang, Li-Mei Lin .(*corresponding author)
  11. Radiation Sensitization of Tumor Cells Induced by Shear Stress: Roles of Integrin Beta-1 and FAK. Annals of Oncology Supplement: (011 #1.165.
    Hui-Ju Ch’ang*, Chi-Wen Luo, Chia-Ching Wu. (*corresponding author)
  12. Shear stress radiosensitizes colon cancer cells by downregulating FAK via integrin β1. 102th AACR annual meeting (2011) Cancer Research 2011, 71 (8 suppl):569.
    Chi-Wen Luo, Chia-Ching Wu, Hui-Ju Mandy Ch’ang*. (*corresponding author)
  13. Loss of Immunolabeling of Kruppel Like Factor 10 is Associated with Advanced Stage and Rapid Progression of Pancreatic Cancer. Annals of Oncology Oct 2010: 21(S8), p73, 197P.
    Hui-Ju Ch’ang*, Hung-Shu Chang, Pei-Yi Chu, Tsui-Lien Mao, Winston C.Y. Yu. (* corresponding author)
  14. Local radiotherapy suppresses granulocyte colony-stimulating factor induced tumor angiogenesis and metastasis. Cancer Research: 100th American Association of Cancer Research 2009 #711.
    Pu-Yuan Chang, Li-Mei Lin, Helen HW Chen, Chuan-Kai Chou, Hui-Ju Mandy Ch’ang*. (*corresponding author)
  15. A phase II study of gemcitabine-based chemoradiotherapy (CCRT) after triplet induction chemotherapy (ICT) for locally advanced pancreatic cancer (LAPC) – a Taiwan Cooperative Oncology Group (TCOG) study. J. Clin. Oncol: American Society of Clinical Oncology 2009 # e15562.
    H. Ch’ang, T. Hwang, H. Wang, M. Chang, Y. Tien, J. Chen, R. Hsieh, P. Lin, Y. Shan, A. Cheng, L. Chen.
  16. Bone Marrow Enhances Intestinal Stromal Cell Proliferation and Protects Intestine from Radiation Damage Through Paracrine Mechanisms. Gordon Research Conference- Radiation Oncology 2008 #10.
    Hui-Ju Ch’ang*, Pu-Yuan Chang, Li-Mei Lin, Ya-Chiun Hsu, I-Min Jen, Helen HW Chen. (* corresponding author)
  17. Phase II Study of Biweekly Gemcitabine Followed by Oxaliplatin and Simplified 48-hr Infusion of 5-Fluorouracil/Leucovorin (GOFL) in Advanced Pancreatic Cancer.J. Clin. Oncol.: ASCO-Gastrointestinal Cancer Symposium 2008 # 221.
    Li-Tzong Chen, Hui-Ju Ch’ang, Chin-Lun Huang, Hsiu-Po Wang, Her-Shyong Shiah, Ming-Chu Chang, Chang-Ming Jan, Jen-Shi Chen, Yu-Wen Tien, Tsann-Long Hwang, Jaw-Town Lin, Ann-Lii Cheng.
  18. Safety-profile of gemcitabine-based chemoradiotherapy (CRT) after triplet induction chemotherapy (CT) in locally advanced pancreatic cancer (LAPC): Preliminary data from Taiwan Cooperative Oncology Group (TCOG) T1204 study. J. Clin. Oncol. ASCO-Gastrointestinal Cancer Symposium 2008 # 156.
    Li-Tzong Chen, Hui-Ju Ch’ang, Chin-Lun Huang, Hsiu-Po Wang, Her-Shyong Shiah, Ming-Chu Chang, Chang-Ming Jan, Jen-Shi Chen, Yu-Wen Tien, Tsann-Long Hwang, Jaw-Town Lin, Ann-Lii Cheng.
  19. Bone marrow cells regulate intestinal repair after radiation via differentiation independent mechanisms. Cancer Research: AACR 2006 # LB-221.
    HJ Ch’ang*, LM Lin, HC Chang, C Lan, YC Hsu, YM Jen, JM Liu, J Whang-Peng. (* corresponding author)
  20. Phase I/II Study of Biweekly Gemcitabine followed by Oxaliplatin and Simplied 48-hr infusion of Fluorouracil / Leucovorin (GOFL) in Pancreatic Cancer J. Clin. Oncol.: ASCO- Gastrointestinal Cancer Symposium 2005 # 147.
    L. Chen, H. Ch’ang, M. Chang, C. Wang, A. Cheng, C. Hsu, C. Jan, S. Chen, T. Liu, J. Chang.
  21. Prediction of Radiotherapy Outcome Using Dynamic Contrast Enhanced MRI of Hepatocellular Carcinoma. Radiat & Oncol: European Society of Therapeutic Radiation Oncology 2004 # 644.
    Ch’ang HJ*, Lien Po-Chin C, Tseng Shou Shou, Hsu C, Shih TTF. (* corresponding author)
  22. Gastrointestinal tract tissue repair after radiation damage is associated with bone marrow reserve. Cancer Research: AACR 2003 # LB112.
    Hui-Ju Ch’ang*, Limei Lin, Shiu-Chen Jeng, Chieh Lan, Jacqueline M. Liu. (* corresponding author)
  23. Target Switching in Radiation Induced Gastrointestinal Death of Mice. Cancer Research: AACR 2002 #101051.
    Hui-Ju Mandy Ch’ang, Francois Paris, Adriana Haimovitz-Friedman, Carlos Cordon-Cardo, Zvi Fuks, Richard Kolesnick.
  24. Potentiation of Taxol Cytotoxicity by Human Urine Extract in MCF7/ADR Cells. Cancer Research: AACR 1999 #4380.
    Hui-Ju Ch’ang, S.E. Chuang, F.C. Liu, Y.F. Chen, C.W. Hsieh, G.M. Lai.
  25. Preoperative Concurrent Chemotherapy and Radiotherapy in Rectal Cancer Patients. 16th Annual Chinese Cancer Society Conference 1997.
    Hui-Ju Ch’ang, James J.M. Jian, Skye H. Cheng, Mei-Ching Liu, Shuh-Yan Leu, Feng-Ming Wang, Stella Y.C. Tsai, Mei-Hua Tsao, Hshu-Hhing Lin, Andrew T. Huang, and Juei-Law Sung.
  26. Postoperative Concurrent Chemotherapy and Radiotherapy for Resectable Locally Advanced Gastric Cancer Patients – A Preliminary Report. 15th Annual Chinese Cancer Society Conference 1996.
    Hui-Ju Ch’ang, Skye H. Cheng, Mei-Chin Liu, James J.M. Jian, Chii-Ming Chen.
  27. Preoperative Concurrent Chemoradiotherapy with Continuous Low Dose Infusion of 5-Fluorouracil and Daily Cisplatinum Injection for Locoregional Esophageal Cancer- A Preliminary Report. 14th Annual Chinese Cancer Society Conference 1995.
    Hui-Ju Ch’ang, Louis Tak Lui, K.H. Yeh, Y.C. Lee, A.L. Cheng.
  28. Comparison of Clinical and Biologic Features between Myeloid and Lymphoid Transformation of Philadelphia Chromosome Positive Chronic Myeloid Leukemia. 84th Chinese Hemotology Society Conference 1993.
    Hui-Ju Ch’ang, Hwei-Fang Tien, Chiu-Hwa Wang, Sou-Ming Chuang, Yao Chang Chen.
  29. Characterization of Philadelphia Chromosome Positive Acute Leukemia. 80th Chinese Hemotology Society Conference 1992.
    Hwei-Fang Tien,Hui-Ju Ch’ang, Chiu-Hwa Wang, Sou-Ming Chuang, Yao Chang Chen.
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